玉屏风颗粒联合冷冻疗法对寻常疣患者的影响  

Effect of Yupingfeng Granules Combined with Liquid Nitrogen Cryotherapy on Patients with Verruca Vulgaris

作　　者：许国新 XU Guoxin(Putian Skin Disease Prevention and Treatment Hospital,Putian 351100,China)

机构地区：[1]莆田市皮肤病防治院,福建莆田351100

出　　处：《中外医学研究》2025年第4期31-34,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨玉屏风颗粒联合液氮冷冻疗法对寻常疣患者的影响。方法:选择2021年6月—2023年12月于莆田市皮肤病防治院接受治疗的88例寻常疣患者,随机分为对照组(44例)、观察组(44例)。观察组采用玉屏风颗粒联合液氮冷冻疗法治疗,对照组采用液氮冷冻疗法治疗,比较两组炎症反应因子水平、免疫功能指标、不良反应及复发情况。结果:治疗4周后,两组免疫球蛋白E(IgE)、CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平较治疗前升高,CD8^(+)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白细胞介素-8(IL-8)水平低于治疗前,且相比对照组,观察组IgE、CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平高,CD8^(+)、TNF-α、CRP、IL-8水平低,差异有统计学意义(P<0.05);两组不良反应发生率、复发率相比,差异无统计学意义(P>0.05)。结论:寻常疣患者采用玉屏风颗粒结合液氮冷冻疗法治疗可改善免疫功能,降低炎症反应因子水平,且不增加不良反应发生率及复发率。Objective:To explore the effect of Yupingfeng Granules combined with liquid nitrogen cryotherapy on patients with verruca vulgaris.Method:A total of 88 patients with verruca vulgaris who received treatment at Putian Skin Disease Prevention and Treatment Hospital from June 2021 to December 2023 were randomly divided into control group(44 cases)and observation group(44 cases).The observation group was treated with Yupingfeng Granules combined with liquid nitrogen cryotherapy,while the control group was treated with liquid nitrogen cryotherapy.The levels of inflammatory response factors,immune function indicators,adverse reactions,and recurrence were compared between the two groups.Result:After 4 weeks of treatment,the levels of immunoglobulin E(IgE),CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)in both groups increased compared to before treatment,while the levels of CD8^(+),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),and interleukin-8(IL-8)were lower than before treatment,compared with the control group,the observation group had higher levels of IgE,CD3^(+),CD4^(+),and CD4^(+)/CD8^(+),and lower levels of CD8^(+),TNF-α,CRP,and IL-8,the differences were statistically significant(P<0.05);there were no statistically significant differences in the incidence of adverse reactions and recurrence rate between the two groups(P>0.05).Conclusion:Yupingfeng Granules combined with liquid nitrogen cryotherapy in the treatment of patients with verruca vulgaris can improve immune function,reduce levels of inflammatory response factors,and not increase the incidence of adverse reactions and recurrence rate.

关 键 词：寻常疣 玉屏风颗粒 液氮冷冻疗法 免疫功能 炎症因子 

分 类 号：R73[医药卫生—肿瘤]