胰岛素不同注射时机对妊娠期糖尿病患者糖脂代谢水平的影响  

Effect of Different Injection Timing of Insulin on Glucose and Lipid Metabolism in Patients with Gestational Diabetes Mellitus

作　　者：练钰敏 杨泰来 郑燕华 LIAN Yumin;YANG Tailai;ZHENG Yanhua(Department of Obstetrics and Gynecology,Ningde City Hospital Affiliated to Ningde Normal University,Ningde 352199,Fujian,China)

机构地区：[1]宁德师范学院附属宁德市医院妇产科,福建宁德352199

出　　处：《糖尿病新世界》2024年第23期17-20,共4页Diabetes New World

摘　　要：目的 分析胰岛素不同注射时机对妊娠期糖尿病患者糖脂代谢水平的影响。方法 回顾性选取2023年1月-2024年7月宁德师范学院附属宁德市医院收治的80例妊娠期糖尿病患者的临床资料,根据治疗方法的不同分为两组,各40例。两组均采用胰岛素治疗,研究组治疗开始时间为孕30周前,对照组治疗开始时间为孕30周后,两组均连续治疗1个月。对比两组糖脂代谢水平、不良反应发生情况、不良妊娠结局发生情况。结果 治疗后,研究组糖化血红蛋白、空腹血糖、低密度脂蛋白胆固醇水平均低于对照组,高密度脂蛋白胆固醇水平高于对照组,差异均有统计学意义(P均<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。研究组不良妊娠结局发生率低于对照组,差异有统计学意义(P<0.05)。结论 妊娠期糖尿病患者在孕30周前开展胰岛素治疗效果更优,可更有效地控制血糖水平并降低不良妊娠结局发生风险,且不会增加药物不良反应。Objective To analyze the effect of different injection timing of insulin on glucose and lipid metabolism in patients with gestational diabetes mellitus.Methods The clinical data of 80 patients with gestational diabetes mellitus admitted to Ningde City Hospital Affiliated to Ningde Normal University from January 2023 to July 2024 were retro-spectively selected and divided into two groups according to different treatment methods,with 40 cases in each group.Both groups were treated with insulin.The study group started treatment before 30 weeks of pregnancy,and the con-trol group started treatment after 30 weeks of pregnancy.Both groups were treated continuously for 1 month.The lev-els of glucose and lipid metabolism,adverse reactions and adverse pregnancy outcomes were compared between the two groups.Results After treatment,the levels of glycated hemoglobin A1c,fasting blood glucose and low-density li-poprotein cholesterol in the study group were lower than those in the control group,and the level of high-density lipo-protein cholesterol was higher than that in the control group,the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The inci-dence of adverse pregnancy outcomes in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The effect of insulin therapy in patients with gestational diabetes mellitus before 30 weeks of pregnancy is better,which can more effectively control blood glucose levels and reduce the risk of adverse pregnancy outcomes,and will not increase the adverse drug reactions.

关 键 词：胰岛素 不同注射时机 妊娠期糖尿病 糖脂代谢 不良妊娠结局 

分 类 号：R71[医药卫生—妇产科学]