胰岛素联合肠内营养支持干预治疗重症糖尿病合并胰腺炎的效果研究  

Study on the Effect of Insulin Combined with Enteral Nutrition Support Intervention in the Treatment of Severe Diabetes Mellitus Complicated with Pancreatitis

作　　者：袁庆杰[1] 侯静 王小芸[2] YUAN Qingjie;HOU Jing;WANG Xiaoyun(Department of Intensive Care Medicine,Weifang Hanting District People's Hospital,Weifang 261100,Shandong,China;Disease Management Center,Weifang Hanting District People's Hospital,Weifang 261100,Shandong,China)

机构地区：[1]潍坊市寒亭区人民医院重症医学科,山东潍坊261100 [2]潍坊市寒亭区人民医院疾病管理中心,山东潍坊261100

出　　处：《糖尿病新世界》2024年第23期40-44,共5页Diabetes New World

摘　　要：目的 探讨肠内营养支持干预联合胰岛素在重症糖尿病合并胰腺炎患者中的应用效果及对营养状态的影响。方法 选择2022年6月-2024年3月潍坊市寒亭区人民医院收治的94例重症糖尿病合并胰腺炎患者为研究对象,根据不同的治疗方法分为两组,各47例。两组均采用常规方法治疗,对照组联合胰岛素治疗,观察组在对照组基础上联合肠内营养支持干预。比较两组血糖水平、营养状态、血清学指标及不良反应发生率。结果 干预后,观察组空腹血糖、餐后2 h血糖、糖化血红蛋白水平均低于对照组,差异均有统计学意义(P均<0.05)。干预后,观察组总蛋白、白蛋白、前白蛋白水平均高于对照组,差异均有统计学意义(P均<0.05)。干预后,观察组超氧化物歧化酶水平高于对照组,活性氧、氧化型谷胱甘肽、白细胞介素-6、白细胞计数以及降钙素原水平均低于对照组,差异均有统计学意义(P均<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 肠内营养支持干预联合胰岛素用于重症糖尿病合并胰腺炎患者中效果良好,能改善患者的营养状态,降低炎症反应和氧化应激反应,且安全性较高。Objective To explore the application effect of enteral nutrition support intervention combined with insulin in patients with severe diabetes mellitus complicated with pancreatitis and its influence on nutritional status.Methods A total of 94 patients with severe diabetes mellitus complicated with pancreatitis admitted to Weifang Hant-ing District People's Hospital from June 2022 to March 2024 were selected as the research objects.According to dif-ferent treatment methods,they were divided into two groups,with 47 cases in each group.Both groups were treated with conventional methods,the control group was treated with insulin,and the observation group was treated with en-teral nutrition support intervention on the basis of the control group.The blood glucose levels,nutritional status,sero-logical indexes and incidence of adverse reactions were compared between the two groups.Results After intervention,the levels of fasting blood glucose,2-hour postprandial blood glucose and glycated hemoglobin A1c in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).After intervention,the levels of total protein,albumin and prealbumin in the observation group were higher than those in the control group,and the differences were statistically significant(all P<0.05).After intervention,the level of superoxide dismutase in the observation group was higher than that in the control group,and the levels of reactive oxygen species,glutathione oxidized,interleukin-6,white blood cell count and procalcitonin were lower than those in the control group,and the differences were statistically significant(all P<0.05).There was no significant difference in the inci-dence of adverse reactions between the two groups(P>0.05).Conclusion The effect of enteral nutrition support inter-vention combined with insulin in patients with severe diabetes mellitus complicated with pancreatitis is good,which can improve the nutritional status of patients,reduce the inflammatory response a

关 键 词：营养支持干预 胰岛素 重症糖尿病 胰腺炎 营养状态 

分 类 号：R473.73[医药卫生—护理学]