二甲双胍和格列苯脲治疗妊娠期糖尿病的疗效与安全性研究  

Study on the Efficacy and Safety of Metformin and Glibenclamide in Gestational Diabetes Mellitus

作　　者：于伟 张美美 朱静云 YU Wei;ZHANG Meimei;ZHU Jingyun(Department of Obstetrics and Gynecology,Shanghe Hospital of Traditional Chinese Medicine,Jinan 251600,Shan-dong,China)

机构地区：[1]商河县中医医院妇产科,山东济南251600

出　　处：《糖尿病新世界》2024年第23期86-88,共3页Diabetes New World

摘　　要：目的 分析二甲双胍和格列苯脲治疗妊娠期糖尿病的疗效与安全性。方法 选取2022年2月-2024年2月商河县中医医院收治的100例妊娠期糖尿病患者,根据治疗方式的不同分为两组。对照组(n=50,二甲双胍+胰岛素治疗),观察组(n=50,二甲双胍+格列苯脲治疗)。比较两组血糖水平及不良妊娠结局发生率。结果 治疗后,观察组各项血糖水平相比于对照组更低,差异均有统计学意义(P均<0.05)。观察组不良妊娠结局发生率低于对照组,差异有统计学意义(P<0.05)。结论 采用二甲双胍联合格列苯脲治疗妊娠期糖尿病的临床疗效较高,可降低不良妊娠结局发生率。Objective To analyze the efficacy and safety of metformin and glibenclamide in the treatment of gesta-tional diabetes mellitus.Methods A total of 100 patients with gestational diabetes mellitus admitted to Shanghe County Hospital of Traditional Chinese Medicine from February 2022 to February 2024 were selected and divided into two groups according to different treatment methods.Control group(n=50,metformin+insulin treatment),observation group(n=50,metformin+glibenclamide treatment).The blood glucose levels and the incidence of adverse pregnancy outcomes were compared between the two groups.Results After treatment,the blood glucose levels in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The in-cidence of adverse pregnancy outcomes in the observation group was lower than that in the control group,and the dif-ference was statistically significant(P<0.05).Conclusion Metformin combined with glibenclamide has a high clinical efficacy in the treatment of gestational diabetes mellitus,which can reduce the incidence of adverse pregnancy out-comes.

关 键 词：二甲双胍 格列苯脲 妊娠期糖尿病 安全性 

分 类 号：R714.256[医药卫生—妇产科学]