改良水脂分离技术定量T2^(*)值及FF值对颈椎间盘退变的应用研究  

Application Research of mDIXON-Quant Quantitative T2^(*)Values and FF Values in Cervical Intervertebral Disc Degeneration

作　　者：刘鹏 牛美晨 刘宏 LIU Peng;NIU Meichen;LIU Hong(Department of CT/MR,Fuyang People's Hospital,Fuyang,236000;The Thirteenth Ward,the Third People's Hospital of Fuyang,Fuyang,236000;Department of Rehabilitation,the Fifth People's Hospital of Fuyang,Fuyang,236000)

机构地区：[1]阜阳市人民医院CT/MR室,阜阳市236000 [2]阜阳市第三人民医院十三病区,阜阳市236000 [3]阜阳市第五人民医院康复科,阜阳市236000

出　　处：《中国医疗器械杂志》2025年第1期61-66,共6页Chinese Journal of Medical Instrumentation

摘　　要：目的探讨磁共振成像改良后的水脂分离(mDIXON-Quant)技术定量T2^(*)值及脂肪分数(FF)值在颈椎间盘退变程度中的临床价值。方法收集阜阳市人民医院2019年3月至2024年1月行常规颈椎MRI及mDIXON-Quant检查的患者118例,测得其C2/3~C6/7椎间盘的T2^(*)值及上、下位椎体FF值,根据普菲尔曼(Pfirrmann)标准对颈椎间盘进行退变程度分级,对不同患者的T2^(*)值及FF值与Pfirrmann分级进行对比,用Spearman相关性分析T2^(*)值、FF值与Pfirrmann分级的相关性。结果在颈椎间盘层面内Ⅰ级、Ⅱ级、Ⅲ级、Ⅳ级、Ⅴ级T2^(*)值全部呈递减趋势(P<0.05)。FF值在上位颈椎椎体的递减顺序为Ⅳ级、Ⅴ级、Ⅲ级、Ⅱ级、Ⅰ级(F=93.28,P<0.05),在下位椎体的递减顺序为Ⅳ级、Ⅲ级、Ⅴ级、Ⅱ级、Ⅰ级(F=112.037,P<0.05)。Spearman相关性分析表明,颈椎间盘T2^(*)值与Pfirrmann分级呈负相关(P<0.05),上、下位椎体FF值与Pfirrmann分级呈正相关(P<0.05)。结论mDIXON-Quant技术定量T2^(*)值及FF值能够应用于颈椎间盘退变,对临床精确诊断、评估治疗效果等具有重要价值。Objective To investigate the clinical value of MRI modified water-lipid separation technique(mDIXONQuant)in terms of T2^(*)values and fat fraction(FF)values for evaluating the degree of cervical intervertebral disc degeneration.Methods A total of 118 patients who underwent routine MRI of the cervical vertebra and the mDIXON-Quant examination in Fuyang People's Hospital from March 2019 to January 2024 were collected.The T2^(*)values of C2/3 to C6/7 intervertebral discs and FF values of the upper and lower vertebral bodies were measured.Cervical intervertebral disc degeneration was graded according to the Pfirrmann criteria.The T2^(*)values and FF values of different patients were compared with the Pfirrmann grades,and the correlation between T2^(*)values,FF values,and Pfirrmann grades was analyzed by Spearman correlation.Results The T2^(*)values of cervical intervertebral discs in grades I,II,III,IV,and V all showed a decreasing trend(P<0.05).The decreasing order of FF values in the upper cervical vertebra was IV,V,III,II,and I(F=93.28,P<0.05),and the decreasing order of FF values in the lower cervical vertebra was IV,III,V,II,and I(F=112.037,P<0.05).Spearman correlation analysis showed that the T2^(*)values of cervical intervertebral discs were negatively correlated with the Pfirrmann grades(P<0.05),and the FF values of the upper and lower vertebrae were positively correlated with the Pfirrmann grades(P<0.05).Conclusion The mDIXON-Quant technique can be used to quantify the T2^(*)values and FF values of cervical intervertebral disc degeneration and plays an important role in accurate clinical diagnosis and evaluation of treatment effects.

关 键 词：颈椎 椎间盘退变 磁共振成像 水脂分离技术 T2^(*)值 FF值 

分 类 号：R139.97[医药卫生—劳动卫生] TH77[医药卫生—公共卫生与预防医学]