依帕司他联合α-硫辛酸静脉滴注治疗糖尿病周围神经病变的效果研究  

Study on effect of epalrestat combined with intravenous infusion ofα-lipoic acid in the treatment of diabetic peripheral neuropathy

作　　者：张斌 ZHANG Bin(Dezhou Municipal Hospital,Dezhou 253012,China)

机构地区：[1]德州市立医院,253012

出　　处：《中国实用医药》2025年第3期30-33,共4页China Practical Medicine

摘　　要：目的探讨糖尿病周围神经病变患者在α-硫辛酸静脉滴注给药基础上联用依帕司他的效果及安全性。方法96例糖尿病周围神经病变患者作为研究样本,入院后均实施甲钴胺静脉注射治疗,根据硬币抛掷法分为对照组和观察组,每组48例。对照组患者采用α-硫辛酸静脉滴注治疗,观察组患者采用依帕司他联合α-硫辛酸静脉滴注治疗。比较两组临床疗效、神经电生理指标、不良反应发生情况。结果观察组治疗总有效率93.75%高于对照组的77.08%,具有统计学差异(P<0.05)。治疗3周后,观察组正中神经运动神经传导速度、腓总神经运动神经传导速度、正中神经感觉神经传导速度、腓总神经感觉神经传导速度分别为(62.02±6.29)、(49.03±5.34)、(48.06±6.25)、(52.48±5.75)m/s,均高于对照组的(52.54±5.31)、(41.72±4.59)、(42.26±5.38)、(46.13±5.04)m/s,具有统计学差异(P<0.05)。观察组不良反应发生率10.42%低于对照组的37.50%,具有统计学差异(P<0.05)。结论糖尿病周围神经病变患者在α-硫辛酸静脉滴注给药基础上联用依帕司他所取得的效果良好,安全性高,值得临床推广应用。Objective To explore the effect and safety of epalrestat combined with intravenous infusion ofα-lipoic acid in the treatment of diabetic peripheral neuropathy.Methods 96 patients with diabetes peripheral neuropathy were selected as the study samples.All patients were treated with mecobalamin intravenous injection after admission.According to coin tossing method,they were divided into a control group and an observation group,with 48 patients in each group.The control group was treated with intravenous infusion ofα-lipoic acid,and the observation group was treated with epalrestat combined with intravenous infusion ofα-lipoic acid.The clinical efficacy,neuroelectrophysiological indicators,and incidence of adverse reactions were compared between the two groups.Results The total effective rate of 93.75%in the observation group was higher than 77.08%in the control group,with statistical difference(P<0.05).After 3 weeks of treatment,the median motor nerve conduction velocity,common peroneal nerve motor nerve conduction velocity,median sensory nerve conduction velocity and common peroneal nerve sensory nerve conduction velocity were(62.02±6.29),(49.03±5.34),(48.06±6.25)and(52.48±5.75)m/s in the observation group,which were higher than(52.54±5.31),(41.72±4.59),(42.26±5.38)and(46.13±5.04)m/s in the control group,with statistical difference(P<0.05).The incidence of adverse reactions of 10.42%in the observation group was lower than 37.50%in the control group,with statistical difference(P<0.05).Conclusion The combination of epalrestat with intravenous infusion ofα-lipoic acid in diabetic peripheral neuropathy patients has achieved good results and high safety,which is worthy of clinical application.

关 键 词：依帕司他 Α-硫辛酸 静脉滴注 糖尿病周围神经病变 效果 

分 类 号：R587.2[医药卫生—内分泌] R747.9[医药卫生—内科学]