缬沙坦氢氯噻嗪对老年原发性高血压患者的效果及安全性分析  

Effect and safety analysis of valsartan and hydrochlorothiazide in elderly patients with essential hypertension

作　　者：刘艳艳 LIU Yan-yan(Department of Pharmacy,Pingshang Town Central Health Center,Junan County,Linyi 276624,China)

机构地区：[1]莒南县坪上镇中心卫生院药库科,276624

出　　处：《中国实用医药》2025年第3期99-102,共4页China Practical Medicine

摘　　要：目的探究老年原发性高血压患者选用缬沙坦氢氯噻嗪治疗的临床效果及用药安全性。方法92例老年原发性高血压患者,按抽签法分为参照组(n=46,采用缬沙坦进行治疗)和联合组(n=46,给予缬沙坦氢氯噻嗪进行治疗)。对比两组血压(收缩压以及舒张压)情况,血清内皮素和一氧化氮,健康调查简表(SF-36)评分,不良反应发生情况。结果治疗后,两组收缩压以及舒张压比治疗前低,且联合组收缩压(119.23±10.17)mm Hg(1 mm Hg=0.133 kPa)以及舒张压(72.37±4.42)mm Hg比参照组的(128.87±11.86)、(77.84±4.63)mm Hg明显更低(P<0.05)。治疗后,两组血清内皮素较治疗前降低、血清一氧化氮较治疗前升高,且联合组血清内皮素(35.27±2.49)ng/L比参照组的(48.46±3.17)ng/L低、血清一氧化氮(58.02±4.56)μmol/L比参照组的(46.28±3.01)μmol/L高(P<0.05)。治疗后,两组SF-36评分较治疗前升高,且联合组SF-36评分(89.97±8.26)分与参照组的(77.62±8.01)分比较更高(P<0.05)。治疗后,联合组不良反应发生率4.35%低于参照组的17.39%(P<0.05)。结论选用缬沙坦氢氯噻嗪治疗老年原发性高血压患者,能有效提升临床效果,帮助患者恢复正常的收缩压、舒张压水平,且能够改善其血清内皮素、血清一氧化氮,使其生活质量大大提升,增强临床用药的安全性。Objective To explore the clinical effect and medication safety of valsartan and hydrochlorothiazide in elderly patients with essential hypertension.Methods 92 elderly patients with essential hypertension were divided into the reference group(n=46,treated with valsartan)and the combination group(n=46,treated with valsartan and hydrochlorothiazide)by lottery method.The blood pressure(systolic blood pressure and diastolic blood pressure),serum endothelin and nitric oxide,36-item short-form healthy survey(SF-36)score and adverse reactions were compared between the two groups.Results After treatment,the systolic blood pressure and diastolic blood pressure in both groups were lower than those before treatment;the systolic blood pressure and diastolic blood pressure were(119.23±10.17)and(72.37±4.42)mm Hg(1 mm Hg=0.133 kPa)in the combination group,which were significantly lower than(128.87±11.86)and(77.84±4.63)mm Hg in the reference group(P<0.05).After treatment,the serum endothelin decreased and the serum nitric oxide were increased in both groups compared with before treatment;the combination group had lower serum endothelin of(35.27±2.49)ng/L than(48.46±3.17)ng/L in the reference group,and higher serum nitric oxide of(58.02±4.56)μmol/L than(46.28±3.01)μmol/L in the reference group(P<0.05).After treatment,the SF-36 score in both groups was higher than that before treatment,and the combination group had higher SF-36 score of(89.97±8.26)points than(77.62±8.01)points in the reference group(P<0.05).After treatment,the incidence of adverse reactions of 4.35%in the combination group was lower than 17.39%in the reference group(P<0.05).Conclusion Valsartan and hydrochlorothiazide in the treatment of elderly patients with essential hypertension can effectively improve the clinical effect,help patients to restore systolic and diastolic blood pressure levels,and improve their serum endothelin and serum nitric oxide,thus greatly improving their quality of life and enhancing the safety of clinical medication.

关 键 词：缬沙坦氢氯噻嗪 老年原发性高血压 临床效果 安全性 

分 类 号：R544.11[医药卫生—心血管疾病]