不同疗程抗菌药物治疗对肝切除术后感染发生率的影响研究  

Study on the effect of different courses of antibiotics on the incidence of infection after hepatectomy

作　　者：舒向阳[1] SHU Xiang-yang(Department of Hepatobiliary Surgery,Feixian County People's Hospital,Linyi 273400,China)

机构地区：[1]费县人民医院肝胆外科,273400

出　　处：《中国实用医药》2025年第3期102-105,共4页China Practical Medicine

摘　　要：目的分析不同疗程抗菌药物治疗对肝切除术后感染发生率的影响。方法选择100例拟行肝切除术的患者为研究对象,按照随机抽样法分为常规组和研究组,各50例。研究组在术前1 h和术后6 h使用抗菌药物治疗,常规组在术前1 h和术后连续3 d使用抗菌药物治疗,且2次/d。比较两组患者术后感染发生率、并发症发生率、手术指标、血常规、体温、肝功能指标、凝血时间。结果研究组术后感染发生率、并发症发生率分别为4.00%、6.00%,常规组分别为6.00%、8.00%。两组患者术后感染发生率、并发症发生率比较,无统计学价值(P>0.05)。两组患者手术时间、术中出血量、尿管留置时间、胃管留置时间、腹腔双套管时间、肝门阻断时间、术后下床活动时间、拆线天数比较,无统计学价值(P>0.05)。常规组白细胞计数为(7.67±2.96)×10^(9)/L、中性粒细胞比率为(73.85±7.34)%、体温为(37.25±0.35)℃,研究组分别为(7.85±2.37)×10^(9)/L、(73.58±6.32)%、(37.14±0.41)℃。两组患者白细胞计数、中性粒细胞比率、体温比较,无统计学价值(P>0.05)。两组患者血清总胆红素、血清丙氨酸氨基转移酶、白蛋白、凝血时间比较,无统计学价值(P>0.05)。结论肝切除术患者使用不同疗程抗菌药物进行治疗的术后感染发生率、并发症发生率并无明显区别,且不会对患者肝功能指标、血常规指标产生明显影响。Objective To analyze the effect of different courses of antibiotics on patients undergoing hepatectomy.Methods A total of 100 patients with proposed hepatectomy were selected as the study subjects and divided into the conventional group and the study group according to random sampling method,with 50 cases in each group.The study group was treated with antibiotics 1 h before surgery and 6 h after surgery,while the conventional group was treated with antibiotics 1 h before surgery and 3 consecutive days after surgery,twice a day.The incidence of postoperative infection,incidence of complications,surgical indexes,blood routine,body temperature,liver function indexes and coagulation time were compared between the two groups.Results The incidence of postoperative infection and complications were 4.00%and 6.00%in the study group,and 6.00%and 8.00%in the conventional group;there was no statistical value in the incidence of postoperative infection and complications between the two groups(P>0.05).There was no statistical value in comparison of operation time,intraoperative blood loss,duration of indwelling urinary catheterization,gastric tube indwelling time,abdominal double cannula time,hepatic portal blocking time,postoperative activity time and days of removing stitches between the two groups(P>0.05).In the conventional group,the white blood cell count was(7.67±2.96)×10^(9)/L,the neutrophil percentage was(73.85±7.34)%and the body temperature was(37.25±0.35)℃,while those in the study group were(7.85±2.37)×10^(9)/L,(73.58±6.32)%and(37.14±0.41)℃;there was no significant difference in white blood cell count,neutrophil percentage and body temperature between the two groups(P>0.05).There was no statistical value in comparison of serum total bilirubin,serum alanine aminotransferase,albumin and coagulation time between the two groups(P>0.05).Conclusion There is no significant difference in the incidence of postoperative infection and complications among patients undergoing hepatectomy treated with different courses

关 键 词：不同疗程 抗菌药物 肝切除 术后感染 

分 类 号：R657.3[医药卫生—外科学]