艾瑞昔布对腰椎间盘突出症患者经皮椎间孔镜术后疼痛的效果研究  

Study on effect of imrecoxib on postoperative pain after pereutaneous transforaminal endoscopic discectomy in patients with lumbar disc herniation

作　　者：刘裕婷 林丽敏 林晓峰 薛厚军 施金婉 蓝雁霞 温娟莹 LIU Yu-ting;LIN Li-min;LIN Xiao-feng(Department of Pharmacy,Sanshui District People's Hospital,Foshan 528000,China)

机构地区：[1]佛山市三水区人民医院药学部,528000

出　　处：《中国实用医药》2025年第3期110-113,共4页China Practical Medicine

基　　金：广东省临床用药研究基金(外科药学骨科镇痛专项基金)(项目编号:2021ZT02)。

摘　　要：目的研究艾瑞昔布对腰椎间盘突出症患者经皮椎间孔镜术后的镇痛效果。方法选取的腰椎间盘突出症患者80例,采用抽签法分为试验组和对照组,每组40例。两组患者均接受经皮椎间孔镜手术治疗,试验组术后开始采用艾瑞昔布进行镇痛治疗,对照组术后未口服任何镇痛药物。比较两组患者术后视觉模拟评分法(VAS)评分,平均住院日,术后24 h内曲马多注射液用量,术后不良反应发生情况。结果术后2、12 h及1、3 d,试验组患者的VAS评分分别为(2.93±0.52)、(2.49±0.40)、(1.92±0.89)、(1.24±0.70)分,均低于对照组的(4.56±0.51)、(3.19±0.75)、(2.75±0.93)、(2.19±0.98)分,差异有统计学意义(P<0.05);而术后5 d,试验组患者的VAS评分虽低于对照组,但无统计学差异(P>0.05)。试验组平均住院日为(7.29±1.57)d,明显短于对照组的(8.38±1.63)d,差异有统计学意义(t=3.046,P<0.05)。试验组术后24 h内曲马多注射液用量为(0.0049±0.022)g,而对照组术后24 h内曲马多注射液用量为(0.1000±0.000)g,比较差异有统计学意义(t=27.339,P<0.05)。试验组术后6、12、24、48、72 h不良反应总发生率分别为12.50%、10.00%、7.50%、2.50%、2.50%,而对照组术后6、12、24、48、72 h不良反应总发生率分别为10.00%、7.50%、5.00%、2.50%、0,两组比较均无统计学差异(χ^(2)=0.125、0.157、0.213、0、1.013,P=0.723、0.692、0.644、1、0.314>0.05)。结论艾瑞昔布对腰椎间盘突出症患者经皮椎间孔镜术后的镇痛效果确切,还可减少曲马多注射液用量,缩短住院时间,具有较好的安全性,有利于患者术后康复。Objective To study the analgesic effect of imrecoxib on postoperative pain after pereutaneous transforaminal endoscopic discectomy in patients with lumbar disc herniation.Methods 80 eligible patients with lumbar disc herniation were selected and divided into an experimental group and a control group by lottery method,with 40 cases in each group.All patients in both groups received pereutaneous transforaminal endoscopic discectomy.The experimental group received imrecoxib for postoperative analgesia,while the control group did not take any analgesic drugs orally after surgery.The postoperative visual analogue scale(VAS)score,average length of hospital stay,dosage of tramadol injection within 24 h after surgery and incidence of adverse reactions were compared between the two groups.Results VAS scores of the experimental group were(2.93±0.52),(2.49±0.40),(1.92±0.89)and(1.24±0.70)points at 2 h,12 h,1 d and 3 d after surgery,which were lower than(4.56±0.51),(3.19±0.75),(2.75±0.93)and(2.19±0.98)points in the control group,and the difference was statistically significant(P<0.05).At 5 d after surgery,VAS score of the experimental group was lower than that of the control group,but there was no statistical difference(P>0.05).The average length of hospital stay in the experimental group was(7.29±1.57)d,which was significantly shorter than(8.38±1.63)d in the control group,and the difference was statistically significant(t=3.046,P<0.05).The dosage of tramadol injection in the experimental group was(0.0049±0.022)g within 24 h after surgery,while that in control group was(0.1000±0.000)g,and the difference was statistically significant(t=27.339,P<0.05).The total incidence of adverse reactions at 6,12,24,48 and 72 h after surgery were 12.50%,10.00%,7.50%,2.50%and 2.50%,while those of the control group were 10.00%,7.50%,5.00%,2.50%and 0;there was no significant difference between the two groups(χ^(2)=0.125,0.157,0.213,0,1.013;P=0.723,0.692,0.644,1,0.314>0.05).Conclusion Imrecoxib has a definite analgesic effect on pat

关 键 词：艾瑞昔布 腰椎间盘突出症 经皮椎间孔镜手术 镇痛 

分 类 号：R687.3[医药卫生—骨科学]