雷公藤甲素肝损伤研究进展  

Research Progress in Triptolide-Induced Live Injury

作　　者：唐千茴 张昊然 张陆勇[1,2] 江振洲[1,3] TANG Qianhui;ZHANG Haoran;ZHANG Luyong;JIANG Zhenzhou(New Drug Screening Center,China Pharmaceutical University,Nanjing Jiangsu 210009,China;Center for Drug Research and Development,Guangdong Pharmaceutical University,Guangzhou Guangdong 510006,China;Jiangsu Center for Pharmacodynamics Research and Evaluation,Nanjing Jiangsu 210009,China)

机构地区：[1]中国药科大学新药筛选中心,江苏南京210009 [2]广东药科大学新药研发中心,广东广州510006 [3]江苏省药效研究与评价服务中心,江苏南京210009

出　　处：《中国药物警戒》2025年第2期121-127,共7页Chinese Journal of Pharmacovigilance

基　　金：国家自然科学基金资助项目(82274200、82074114、81973562、81773995)。

摘　　要：目的总结雷公藤甲素肝毒性机制的相关研究,为了解雷公藤甲素诱发药物性肝损伤的机制提供依据。方法通过文献检索与分析,从直接毒性和间接毒性两方面总结雷公藤甲素诱发药物性肝损伤的机制。结果雷公藤甲素肝毒性机制涉及肝细胞氧化应激、线粒体损伤、代谢异常、NKT细胞激活、辅助性T淋巴细胞与调节性T淋巴细胞失衡、肝脏对炎性刺激的敏感性增加等。结论雷公藤甲素肝毒性机制复杂,直接毒性作用靶点广泛,间接毒性具有更强的隐匿性和复杂性,雷公藤甲素肝毒性的研究可为雷公藤及其制剂的增效减毒以及临床安全合理用药提供理论参考。Objective To summarize the research progress in the hepatotoxicity mechanism of triptolide and shed light on the mechanism of drug-induced liver injury caused by triptolide.Methods Based on literature research,the mechanism of drug induced liver injury caused by triptolide was summarized in terms of direct toxicity and indirect toxicity.Results The hepatotoxic mechanism of triptolide involved oxidative stress,mitochondrial damage,metabolic abnormalities,activation of NKT cells,imbalance between T helper cells and regulatory T cells,and increased liver sensitivity to inflammatory stimuli.Conclusion The hepatotoxicity mechanism of triptolide is complex,as there are a wide range of targets for direct toxicity.In addition,the indirect toxicity is highly concealed and complex.The elucidation of mechanisms of hepatotoxicity caused by triptolide provides a reference for enhancing the efficacy and reducing the toxicity of Tripterygium wilfordii Hook.f.and its preparations as well as for clinical safety and rational drug use.

关 键 词：雷公藤 雷公藤甲素 肝损伤 肝毒性 直接毒性 间接毒性 机制研究 

分 类 号：R965.3[医药卫生—药理学] R994.11[医药卫生—药学]