某市精神卫生中心安神类中成药用药分析  

Usage of Nerve-Calming Chinese Herbal Patent Medicines in a Mental Health Center

作　　者：周坤 马良 李肇丰 曹斌 顾洪伟 刘茜 ZHOU Kun;MA Liang;LI Zhaofeng;CAO Bing;GU Hongwei;LIU Qian(Department of Pharmacy,Wuhan Mental Health Center,Wuhan Hubei 430012,China;Department of Pharmacy,Wuhan Hospital for Psychotherapy,Wuhan Hubei 430012,China)

机构地区：[1]武汉市精神卫生中心药学部,湖北武汉430012 [2]武汉市心理医院药学部,湖北武汉430012

出　　处：《中国药物警戒》2025年第2期211-216,共6页Chinese Journal of Pharmacovigilance

基　　金：国家自然科学基金资助项目(81901302);武汉市医学科研项目(WZ20Q02)。

摘　　要：目的调查某市精神卫生中心安神类中成药应用情况,为安神类中成药合理和规范使用提供参考。方法采用逸耀合理用药软件对中心医院信息系统(Hospital Information System,HIS)2018至2023年安神类中成药门诊处方进行审核,统计各品种用药天数、计算用药频度(Defined Daily Dose,DDDs)、限定日费用(Defined Daily Cost,DDC)和药物利用指数(Drug Utilization Index,DUI)以评估用药合理性。结果2018~2023年DDDs排名前5位分别为甜梦口服液、疏肝解郁胶囊、解郁丸、健脑胶囊和舒眠胶囊;各品种安神中成药DUI介于0.30~0.99;123989张中成药处方中筛查出6657张不合理处方,不合理率5.37%,其中不合理类型以无适应证用药(13.70%)、用法用量不适宜(12.36%)和遴选药品不适宜(2.60%)为主。结论2018至2023年安神类中成药使用量平稳增长,使用整体合理、规范,不合理用药发生率低,但仍应警惕甜梦口服液、解郁丸、巴戟天寡糖胶囊等可能发生不合理用药情况。Objective To investigate the usage of Chinese herbal patent medicines for calming nerves in a mental health center and to provide references for rational use of related drugs.Methods The YI-Yao Rational Drug Use Software System was used to review the prescriptions for nerve-calming Chinese herbal patent medicines from the Hospital Information System(HIS).The rationality of drug use was evaluated in terms of the days of drug use,defined daily dose(DDDs),defined daily cost(DDC)and drug utilization index(DUI).Results The top five drugs in terms of DDDs between 2018 and 2023 were Tian-meng oral liquid,Shu-gan-Jie-yu capsules,Jie-yu pills,Jian-nao capsules and Shu-mian capsules,and DUI ranged from 0.30 to 0.99.A total of 6657 improper prescriptions were screened out of 123989 prescriptions for Chinese herbal patent medicines,so the rate of substandard prescriptions was 5.37%involving prescriptions for wrong indications(13.70%),inappropriate usage and dosage(12.36%),and inappropriate selection of drugs(2.60%).Conclusion From 2018 to 2023,the total usage and varieties of Chinese herbal patent medicines increased stably.Despite the low incidence rate of irrational use of these drugs,clinicians need to use some varieties with caution.

关 键 词：安神类中成药 用药频度 限定日费 药物利用指数 用药分析 合理用药 精神卫生中心 

分 类 号：R971[医药卫生—药品] R994.11[医药卫生—药学]