万古霉素骨粉低剂量局部应用致红人综合征1例分析  

One Case of Red Man Syndrome Caused by Locally-Used Low-Dose Vancomycin

作　　者：李小波 周国坚 黄玉玲 李海俏 陈婷婷 LI Xiaobo;ZHOU Guojian;HUANG Yuling;LI Haiqiao;CHEN Tingting(Department of Pharmacy,Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine,Zhuhai Guangdong 519020,China)

机构地区：[1]珠海市中西医结合医院药学部,广东珠海519020

出　　处：《中国药物警戒》2025年第2期217-220,226,共5页Chinese Journal of Pharmacovigilance

基　　金：珠海市科技创新局2023年珠海市社会发展领域科技计划资助项目(2320004000099)。

摘　　要：目的分析万古霉素低剂量局部应用致红人综合征(RMS)的临床特征及致敏机制,警示其用药风险,为临床合理用药提供参考。方法分析1例低剂量万古霉素骨粉局部应用预防手术部位感染(SSI)诱发RMS的案例,经药品不良反应(ADR)监测和文献回顾讨论其机制,并探索其药学监护。结果根据ADR关联性评价、诺氏量表评分和致敏机制分析,考虑万古霉素致RMS,同时开展ADR监测和药学监护,患者RMS症状好转治愈。结论低剂量万古霉素局部应用同样存在发生RMS的风险,临床需警惕和重视。Objective To analyze the clinical characteristics and sensitization mechanisms of red man syndrome(RMS)induced by locally-used low-dose vancomycin,warn of associated risks and provide a reference for pharmacovigilance.Methods One case of RMS caused by low dose vancomycin locally used for prevention of surgical site infections(SSIs)was reported.The mechanism was studied based on ADR monitoring and a literature review while related pharmaceutical care was traced.Results According to the correlation evaluation of ADR,the score of Naranjo’s scale and an analysis of sensitization mechanisms,vancomycin was considered to have caused RMS,so clinical pharmacists initiated adverse reaction monitoring and pharmaceutical care,and the symptoms of RMS were improved and disappeared.Conclusion Even locally-used low-dose vancomycin can potentially induce RMS,which is why pharmacovigilance is recommended.

关 键 词：万古霉素 红人综合征 手术部位感染 低剂量 局部应用 药品不良反应 

分 类 号：R916.693[医药卫生—药学] R994.11