基础胰岛素联合西格列汀对继发性糖尿病患者血糖控制的影响研究  

Effect of Basic Insulin Combined with Selegiline on Blood Glucose Control in Patients with Secondary Diabetes Mellitus

作　　者：陈娇 张德利[2] 刘万森[1] CHEN Jiao;ZHANG Deli;LIU Wansen(Department of Renal Rheumatology,Linqu County People's Hospital,Weifang 262600,Shandong,China;Department of Endocrinology,Linqu County People's Hospital,Weifang 262600,Shandong,China)

机构地区：[1]临朐县人民医院肾病风湿科,山东潍坊262600 [2]临朐县人民医院内分泌科,山东潍坊262600

出　　处：《糖尿病新世界》2024年第22期101-103,119,共4页Diabetes New World

摘　　要：目的 探讨基础胰岛素联合西格列汀对长期口服糖皮质激素所致继发性糖尿病(diabetes mellitus, DM)患者血糖控制的效果。方法 选取2022年1月-2024年6月临朐县人民医院收治的80例长期口服糖皮质激素致继发性DM患者为研究对象,根据不同的治疗方法分为两组,每组40例。常规组进行基础胰岛素治疗,探究组进行基础胰岛素联合西格列汀治疗。比较两组血糖水平、胰岛功能、并发症发生率。结果 治疗后,探究组空腹血糖、餐后2 h血糖、糖化血红蛋白、空腹胰岛素、胰岛素抵抗指数均低于常规组,胰岛β细胞功能指数高于常规组,差异均有统计学意义(P均<0.05)。探究组并发症发生率低于常规组,差异有统计学意义(P<0.05)。结论 基础胰岛素联合西格列汀治疗长期口服糖皮质激素所致继发性DM患者,能更有效地控制血糖水平,改善胰岛功能,且未显著增加并发症发生的风险。Objective To investigate the effect of basal insulin combined with sitagliptin on blood glucose control in patients with secondary diabetes mellitus(DM)caused by long-term oral glucocorticoid.Methods From January 2022 to June 2024,80 patients with secondary DM caused by long-term oral glucocorticoids admitted to Linqu County People's Hospital were selected as the research objects.According to different treatment methods,they were divided into two groups,40 cases in each group.The conventional group was treated with basic insulin,and the exploration group was treated with basal insulin combined with sitagliptin.The blood glucose level,islet function and complica-tion rate were compared between the two groups.Results After treatment,the fasting plasma glucose,2-hour postpran-dial plasma glucose,glycated hemoglobin A1c,fasting insulin and homeostasis model assessment-insulin resistance in the exploration group were lower than those in the conventional group,and the homeostasis model assessment of β-cell function was higher than that in the conventional group,the differences were statistically significant(all P<0.05).The incidence of complications in the exploration group was lower than that in the conventional group,and the difference was statistically significant(P<0.05).Conclusion Basal insulin combined with sitagliptin in the treatment of patients with secondary DM caused by long-term oral glucocorticoids can more effectively control blood glucose levels and im-prove islet function,without significantly increasing the risk of complications.

关 键 词：继发性糖尿病 基础胰岛素 西格列汀 血糖控制 胰岛功能 

分 类 号：R59[医药卫生—内科学]