咸宁地区成人甲状腺结节患病情况与危险因素分析  

Analysis of the prevalence and risk factors of adult thyroid nodules in Xianning area

作　　者：陈赟 何瑶 黄倩 Chen Yun;He Yao;Huang Qian(Department of Endocrinology,Xianning Hubei,437000,China;Geriatrics of Xianning Central Hospital,Xianning Hubei,437000,China)

机构地区：[1]咸宁市中心医院内分泌科,湖北咸宁437000 [2]咸宁市中心医院老年病科,湖北咸宁437000

出　　处：《遵义医科大学学报》2025年第2期176-181,共6页Journal of Zunyi Medical University

基　　金：咸宁市中心医院院内科研项目(NO:2023-02)。

摘　　要：目的调查咸宁地区成人甲状腺结节的患病特点,探讨影响其患病的因素,为该地区甲状腺结节的防治提供理论支撑。方法865名入组对象(均完成甲状腺功能检测)进行问卷调查,完善尿碘测定、促甲状腺激素(TSH)、游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、甲状腺过氧化物酶抗体(TPOAb)和甲状腺球蛋白抗体(TGAb)、甲状腺彩超。采用SPSS 23.0软件进行t检验、秩和检验和χ^(2)检验,采用Pearson进行相关性分析,采用多因素logistic回归分析影响甲状腺结节患病因素。结果865名居民尿碘中位数为189.1μg/L,男性(173.8μg/L)低于女性(196.7μg/L),差异有统计学意义(Z=-2.348,P=0.006);县区居民(178.4μg/L)低于市区居民尿碘中位数(189.2μg/L),差异有统计学意义(Z=-3.491,P=0.008);非甲状腺结节组尿碘中位数(168.4μg/L)低于甲状腺结节组(194.3μg/L),差异有统计学意义(Z=-2.261,P=0.016)。甲状腺结节检出率为29.83%,其中男性(21.52%)低于女性(39.26%),差异有统计学意义(χ^(2)=32.38,P=0.018);比较不同年龄段人群结节检出率,差异有统计学意义(χ^(2)=59.22,P=0.009)。多因素Logistic回归分析提示,女性(OR=1.06,95%CI:1.02~1.09)、高龄(OR=3.58,95%CI:2.91~4.28)、吸烟(OR=1.54,95%CI:1.46~1.63)和甲状腺疾病家族史(OR=1.59,95%CI:1.32~2.43)为甲状腺结节的危险因素。结论咸宁地区体检和就诊人群甲状腺结节患病率较高,应加强对女性、高龄、吸烟、甲状腺疾病家族史人群的甲状腺结节筛查工作。Objective To investigate the characteristics of adult thyroid nodules in Xianning area,explore the factors affecting their incidence,and provide theoretical support for the prevention and treatment of thyroid nodules in this area.Methods A questionnaire survey was conducted on 865 enrolled subjects(all of whom had completed thyroid function testing)to improve urinary iodine measurement,thyroid stimulating hormone(TSH),free triiodothyronine(FT 3),free thyroxine(FT 4),thyroid peroxidase antibody(TPOAb),thyroid globulin antibody(TGAb),and thyroid ultrasound.SPSS 23.0 software was used for t-test,rank sum test,and chi square test.Pearson was used for correlation analysis,and multiple logistic regression was used to analyze the factors affecting the incidence of thyroid nodules.Results The median urinary iodine level among the 865 residents was 189.1μg/L,with males(173.8μg/L)lower than females(196.7μg/L),and the difference was statistically significant(Z=-2.348,P=0.006);The median urinary iodine level of county residents(178.4μg/L)was lower than that of urban residents(189.2μg/L),and the difference was statistically significant(Z=-3.491,P=0.008);The median urinary iodine level in the non thyroid nodule group(168.4μg/L)was lower than that in the thyroid nodule group(194.3μg/L),and the difference was statistically significant(Z=-2.261,P=0.016).The detection rate of thyroid nodules was 29.83%,with males(21.52%)lower than females(39.26%),and the difference was statistically significant(χ^(2)=32.38,P=0.018);The difference in nodule detection rates among different age groups was statistically significant(χ^(2)=59.22,P=0.009).Multivariate logistic regression analysis suggested that female(OR=1.06,95%CI:1.02-1.09),advanced age(OR=3.58,95%CI:2.91-4.28),smoking(OR=1.54,95%CI:1.46-1.63),and family history of thyroid disease(OR=1.59,95%CI:1.32-2.43)are risk factors for thyroid nodules.Conclusion The incidence of thyroid nodules is relatively high among the population undergoing physical examination and medical treatment

关 键 词：结节 甲状腺 流行 危险因素 

分 类 号：R581[医药卫生—内分泌]