PTH、SOST、AHSG和VitD与非透析慢性肾脏病血管钙化的相关性  

Correlation between PTH,SOST,AHSG,VitD and vascular calcification in non-dialysis chronic kidney disease

作　　者：郭云剑 汤富平 黎林 Guo Yun-jian;Tang Fu-ping;Li Lin(Department of Nephrology,Shangrao Municipal Hospital,Shangrao 334000,Jiangxi,China)

机构地区：[1]上饶市立医院肾内科,江西上饶334000

出　　处：《四川生理科学杂志》2025年第2期265-267,共3页

基　　金：上饶市科技计划社会发展领域医疗卫生指导性项目(编号:2023CZDX128)。

摘　　要：目的:探讨甲状旁腺激素(Parathyroidhormone,PTH)、骨硬化蛋白(Sclerostin,SOST)、胎球蛋白A(Human fetuinA,AHSG)和维生素D(VitaminD,VitD)与非透析慢性肾脏病(Chronickidneydisease,CKD)血管钙化(Vascularcalcification,VC)患者的相关性。方法:选取上饶市立医院2023年12月至2024年6月收治的非透析CKD患者66例为研究对象,根据是否发生VC将患者分为VC组和非VC组。收集患者基础资料、实验室指标,并进行比较分析;以Logistic回归分析法分析PTH、SOST、AHSG和VitD与非透析CKD患者发生VC的相关性。结果:本研究共纳入66例非透析CKD患者,发生VC的患者共24例(36.36%)。VC组在性别、年龄、身高、体质量、平均动脉压、基础疾病、吸烟、饮酒等基础资料与无VC组对比,未见显著差异(P>0.05);VC组PTH高于无VC组,SOST、AHSG及1,25-二羟维生素D3(1,25–dihydroxyvitaminD3,1,25-(OH)2D3)低于无VC组(P<0.05);经多因素Logistic回归分析示,PTH、SOST、AHSG及1,25-(OH)2D3是非透析CKD患者发现VC的独立危险因素(P<0.05)。结论:PTH、SOST、AHSG及VitD与非透析CKDVC患者密切相关。Objective:To investigate the correlation between PTH,SOST,AHSG,VitD and VC in patients with non-dialysis CKD.Methods:Sixty-six patients with non-dialysis CKD who were admitted to Shangrao Municipal Hospital from December 2023 to June 2024 were selected as the research subjects.They were divided into VC group and non-VC group according to whether VC occurred.Basic information and laboratory indicators of patients enrolled were collected and comparatively analyzed.Logistic regression analysis was used to analyze the correlation between PTH,SOST,AHSG,VitD and the occurrence of VC in patients with non-dialysis CKD.Results:In this study,24 patients developed VC,accounting for 36.36%.There was no significant difference between the VC group and the non-VC group in terms of gender,age,height,body mass,mean arterial pressure,underlying diseases,smoking,and drinking(P>0.05).PTH level in the VC group was higher than that in the non-VC group.The level of SOST,AHSG and (1,25-(OH)2D3)were lower than those in the non-VC group(P<0.05).Multivariate logistic regression analysis showed that PTH,SOST,AHSG,and 1,25-(OH)2D3 were independent risk factors for VC in patients with non-dialysis CKD(P<0.05).Conclusion:PTH,SOST,AHSG,and VitD are closely related to VC in patients with non-dialysis CKD.

关 键 词：慢性肾脏病 血管钙化 甲状旁腺激素 骨硬化蛋白 胎球蛋白A 维生素D 

分 类 号：R69[医药卫生—泌尿科学]