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作 者:宋莹 戢瑞莉 刘冬冬 Song Ying;Ji Rui-li;Liu Dong-dong(Department of Rehabilitation,Shunde Hospital,Guangzhou University of Chinese Medicine,Foshan 528300,Guangdong,China;Department of Clinical Laboratory,Shunde Hospital,Guangzhou University of Chinese Medicine,Foshan 528300,Guangdong,China;Department of Clinical Laboratory,The Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510000,China)
机构地区:[1]广州中医药大学顺德医院(佛山市顺德区中医院)康复科,广州佛山528300 [2]广州中医药大学顺德医院(佛山市顺德区中医院)检验科,广州佛山528300 [3]广州中医药大学第二附属医院检验科,广东广州510000
出 处:《四川生理科学杂志》2025年第2期275-277,452,共4页
基 金:顺德区竞争性扶持人才项目专项基金(编号:SDRC20220008)
摘 要:目的:探讨二甲双胍联合穴位埋线在肥胖型多囊卵巢综合征患者中的应用效果,并分析对性激素及妊娠情况的影响。方法:根据随机数字表法将2022年01月至2022年12月期间我院收治的62例肥胖型多囊卵巢综合征患者分为接受二甲双胍治疗的对照组(n=31)和给予二甲双胍结合穴位埋线治疗的联合组(n=31),对比两组临床疗效、性激素水平、脂肪细胞因子、妊娠相关情况。结果:治疗3 m后,联合组治疗总有效率高于对照组(P<0.05);治疗3m后,两组卵泡刺激素等性激素指标水平均低于治疗前,且联合组均低于对照组(P<0.05);治疗3m后,两组瘦素水平均低于治疗前,且联合组低于对照组(P<0.05),脂联素和25-羟维生素D水平均高于治疗前,且联合组高于对照组(P<0.05);联合组恢复排卵率和妊娠率均高于对照组(χ^(2)=4.724、5.248,P=0.030、0.022)。结论:二甲双胍结合穴位埋线能改善肥胖型多囊卵巢综合征患者的性激素、脂肪细胞因子和25-羟维生素D的表达水平,有利于恢复排卵率、妊娠率的提升,治疗效果显著,值得临床推广应用。Objective:To investigate the effect of metformin combined with acupoint embedding in obese patients with polycystic ovary syndrome(PCOS),and analyze the effects on sex hormones and pregnancy.How:According to the random number table method,62 obese patients with PCOS admitted to our hospital from January 2022 to December 2022 were divided into metformin treatment control group(n=31)and metformin combined with acupoint embedding therapy group(n=31).The clinical efficacy,sex hormone levels,adipocytokines and pregnancy-related conditions were compared between the two groups.Results:After 3 months of treatment,the total effective rate of the combined group was higher than that of the control group(P<0.05).After 3 months of treatment,the levels of FSH and other sex hormone indexes in 2 groups were lower than before treatment,combination group were lower than control group(P<0.05).After 3 months of treatment,leptin levels in both groups were lower than before treatment,the levels of adiponectin and 25-hydroxyvitamin D in combination group were lower than control group(P<0.05),the levels of adiponectin and 25-hydroxyvitamin D in combination group were higher than control group(P<0.05).The ovulation recovery rate and pregnancy rate of the combined group were higher than the control group(χ^(2)=4.724,5.248,P=0.030,0.022).Conclusion:Metformin combined with acupoint catch-embedding can improve the expression levels of sex hormones,adipocytokines and 25-hydroxyvitamin D in obese patients with polycystic ovary syndrome,which is conducive to the recovery of ovulation rate and the improvement of pregnancy rate,and the therapeutic effect is significant,worthy of clinical promotion and application.
关 键 词:二甲双胍 埋线 肥胖型多囊卵巢综合征 女性激素 瘦素
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