风湿性关节炎患者类风湿因子、血沉、白细胞介素-6水平与类风湿性关节炎活动程度及临床疗效的相关性分析  

Correlation analysis of rheumatoid factor,erythrocyte sedimentation rate and interleukin-6 levels with rheumatoid arthritis activity and clinical efficacy in patients with rheumatoid arthritis

作　　者：魏建华 Wei Jian-hua(Department of Endocrinology,Nephropathy,Rheumatology and Immunology,Guangshan People's Hospital,Xinyang 465400,Henan,China)

机构地区：[1]光山县人民医院内分泌肾病风湿免疫科,河南信阳465400

出　　处：《四川生理科学杂志》2025年第2期313-315,455,共4页

摘　　要：目的:探讨类风湿因子(RF)、血沉(ESR)、白细胞介素-6(IL-6)水平与类风湿性关节炎活动程度的相关性。方法:选取2020年7月-2023年4月期间本院收治的121例类风湿性关节炎患者作为研究对象。根据DAS28评分[6]评估患者病情,将患者分为中高活动期组(n=54)及低活动期组(n=67)。另选取60例同期健康体检者为健康组。对比三组及不同临床疗效患者入院时RF、ESR、IL-6水平,并分析其相关性。ROC曲线分析入院时RF、ESR、IL-6水平检测对患者临床疗效的预测价值。结果:类风湿性关节炎患者入院时RF、ESR、IL-6均显著高于健康体检者,并随活动度增加而升高;中高活动期患者晨僵、休息痛及stoke指数均显著高于低活动期患者(P<0.05)。入院时,RF、ESR、IL-6与DAS28评分均呈正相关(P<0.05)。入院时,不同临床疗效患者RF、ESR、IL-6水平比较,治疗无效>治疗有效>治疗显效,组间差异均有统计学意义(P<0.05)。入院时,RF、ESR、IL-6水平联合预测类风湿性关节炎治疗无效的AUC为809,最佳敏感度、特异度分别为77.27%、81.61%。结论:类风湿性关节炎患者RF、ESR、IL-6水平与疾病活动程度及临床疗效密切相关,早期检测其水平对临床诊疗具有重要价值。Objective:To investigate the correlation between the levels of rheumatoid factor(RF),erythrocyte sedimentation rate(ESR)and interleukin-6(IL-6)and the degree of rheumatoid arthritis activity.Methods:121 patients with rheumatoid arthritis admitted to our hospital from July 2020 to April 2023 were selected as the study objects.According to DAS28 score[6],the patients'condition was evaluated,and the patients were divided into medium-high activity group(n=54)and low-activity group(n=67).Another 60 healthy subjects were selected as the healthy group.The levels of RF,ESR and IL-6 were compared among the three groups and patients with different clinical efficacy at admission,and the correlation was analyzed.ROC curve was used to analyze the predictive value of RF,ESR and IL-6 levels on admission to patients.Results:RF,ESR and IL-6 in patients with RA were significantly higher than those in healthy subjects,and increased with the increase of activity.Morning stiffness,rest pain and stoke index in patients with middle and high activity period were significantly higher than those in patients with low activity period(P<0.05).At admission,RF,ESR,IL-6 and DAS28 scores were positively correlated(P<0.05).At admission,the levels of RF,ESR and IL-6 in patients with different clinical efficacy were compared,treatment ineffective>treatment effective>treatment obvious,with statistical significance between groups(P<0.05).At admission,the AUC of RF,ESR,and IL-6 combined predicted the failure of RA treatment was 809,and the best sensitivity and specificity were 77.27%and 81.61%,respectively.Conclusion:The levels of RF,ESR and IL-6 in patients with rheumatoid arthritis are closely related to the degree of disease activity and clinical efficacy,and early detection of their levels is of great value for clinical diagnosis and treatment.

关 键 词：类风湿因子 血沉 降钙素原 类风湿性关节炎 活动程度 

分 类 号：R593.22[医药卫生—内科学]