血清ALB、sTREM-1、CF-6对新生儿坏死性小肠结肠炎的预测价值研究  

Study on the predictive value of serum ALB,sTREM-1 and CF-6 in necrotizing enterocolitis of newborn

作　　者：黄晶晶 Huang Jing-jing(Department of Neonatology,Pingqiao Maternal and Child Health Hospital,Xinyang 464100,Henan,China)

机构地区：[1]信阳市平桥妇幼保健院新生儿科,河南信阳464100

出　　处：《四川生理科学杂志》2025年第2期316-318,共3页

摘　　要：目的:探讨血清白蛋白(Albumin,ALB)、胰岛素样生长因子-1(Insulin-like growth factor 1,IGF-1)、可溶性髓系细胞触发受体-1(Soluble myeloid cell trigger receptor-1,sTREM-1)联合检测对新生儿坏死性小肠结肠炎(Necrotizing enterocolitis,NEC)的预测效能。方法:选取2020年6月至2023年4月期间本院收治的64例NEC患儿纳入研究组(n=64);另选取本院同期128例健康新生儿纳入对照组。检测对比两组出生1、3 d时血清ALB、IGF-1、sTREM-1水平。对比不同疾病分期患儿出生1、3 d及病发入院1 d、3 d时血清各指标水平。分析出生1、3 d时血清各指标联合检测对NEC的预测价值。结果:对照组出生1 d、3 d时血清ALB、IGF-1水平均明显高于研究组;血清sTREM-1水平明显低于研究组(P<0.05);出生1 d、3 d时及入院1 d、3 d时血清ALB、IGF-1水平比较,Ⅰ期>Ⅱ期>Ⅲ期、血清sTREM-1水平比较,Ⅰ期>Ⅱ期>Ⅲ期(P<0.05);出生1 d、3 d时血清ALB、IGF-1、sTREM-1水平联合预测NEC的曲线下面积分别为0.739、0.747。结论:血清ALB、IGF-1、sTREM-1联合检测对NEC具有较高的预测价值,血清ALB、IGF-1、sTREM-1与临床病情程度密切相关。Objective:To investigate serum Albumin(ALB),Insulin-like growth factor 1(IGF-1),Soluble myeloid cell trigger receptor-1(sTREM-1)combined assay for Necrotizing enterocolitis in newborns(NEC)predictive performance.Methods:Sixty-four NEC infants admitted to our hospital from June 2020 to April 2023 were selected as the study group(n=64);another 128 healthy newborns admitted to our hospital during the same period were selected as the control group.The levels of serum ALB,IGF-1,and sTREM-1 were measured and compared between the two groups at birth and on the 1st and 3rd day after birth.The levels of each serum indicator were compared between infants with different disease stages at birth and on the 1st and 3rd day after birth,as well as on the 1st and 3rd day after admission.The predictive value of combined detection of serum indicators at birth and on the 1st and 3rd day after birth for NEC was analyzed.Results:The serum levels of ALB and IGF-1 in the control group were significantly higher than those in the study group at 1 and 3 days after birth,while the serum level of sTREM-1 was significantly lower than that in the study group(P<0.05).Serum ALB and IGF-1 levels were compared at 1 and 3 days after birth and at 1 and 3 days after admission,stage Ⅰ>Stage Ⅱ>stage Ⅲ,and serum sTREM-1 levels were compared at stage Ⅰ<stage Ⅱ<stage Ⅲ(P<0.05).The area under the curve of NEC predicted by serum ALB,IGF-1 and sTREM-1 levels at 1 and 3 days of birth was 0.739 and 0.747,respectively.Conclusion:Serum ALB,IGF-1 and sTREM-1 combined detection has high predictive value for NEC,and serum ALB,IGF-1 and sTREM-1 are closely related to the clinical severity of NEC.

关 键 词：白蛋白、胰岛素样生长因子-1 可溶性髓系细胞触发受体-1 新生儿坏死性小肠结肠炎 

分 类 号：R56[医药卫生—呼吸系统]