化痰理肺定喘汤联合噻托溴铵对老年哮喘-慢阻肺重叠综合征的治疗效果分析  

Effect analysis of Huatan Lifei Dinghuan Decoction combined with Tiotropium bromide on senile asthma-COPD overlap syndrome

作　　者：程建生 Cheng Jian-sheng(Department of Integrative Medicine,Luohe Hospital of Traditional Chinese Medicine,Luohe 462300,Henan,China)

机构地区：[1]漯河市郾城区中医院中西医结合内科,河南漯河462300

出　　处：《四川生理科学杂志》2025年第2期319-321,402,共4页

摘　　要：目的:探讨化痰理肺定喘汤联合噻托溴铵治疗老年哮喘-慢阻肺重叠综合征(Asthma-COPD overlap syndrome,ACOS)的临床效果。方法:回顾性收集2020年8月至2023年8月期间采用噻托溴铵治疗的37例老年ACOS患者资料,纳入对照组;采集同时期本院采用化痰理肺定喘汤联合噻托溴铵治疗的老年ACOS患者38例患者资料,纳入研究组。分析比较两组治疗前后中医证候积分、哮喘控制测试(Asthma control test,ACT)、慢阻肺评估测试(COPD assessment test,CAT)、用力肺活量(Forced vital capacity,FVC)、第一秒用力呼吸容积(Forced respiratory volume in the first second,FEV_(1))、最大呼气流量(Maximum expiratory flow,PEF)、白介素-6(Interleukin-6,IL-6)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)、C-反应蛋白(C-reactive protein,CRP)以及不良反应。结果:治疗后,研究组各证候积分均显著低于对照组(P<0.05)。治疗后,研究组的ACT评分显著高于对照组,CAT评分显著低于对照组(P<0.05)。治疗后,研究组的FVC、FEV_(1)、PEF均显著高于对照组(P<0.05)。治疗后,研究组的IL-6、TNF-α、CRP均显著低于对照组(P<0.05)。两组治疗期间均未发生不良反应。结论:化痰理肺定喘汤联合噻托溴铵治疗老年ACOS患者,能缓解临床症状,改善肺功能,减轻炎症反应,且安全性好。Objective:To investigate the clinical effect of Huatan Lifei Dingchuan Decoction combined with tiotropium bromide in the treatment of senile asthma-copd overlap syndrome(ACOS).Methods:The data of 37 elderly patients with ACOS treated with tiotropium bromide from August 2020 to August 2023 were retrospectively collected and included in the control group.Data of 38 elderly ACOS patients treated with Huatan Lifei Dingchuan Decoction combined with tiotropium bromide were collected and included in the study group.The TCM syndrome scores,asthma control test(ACT),COPD assessment test(CAT),forced vital capacity(FVC),forced respiratory volume in the first second(FEV1),maximum expiratory flow(PEF),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),and adverse reactions were analyzed and compared between two groups before and after treatment.Results:After treatment,the syndrome scores of the study group were significantly lower than those of the control group(P<0.05).After treatment,the ACT score of the study group was significantly higher than that of the control group,and the CAT score was significantly lower than that of the control group(P<0.05).After treatment,FVC,FEV1 and PEF in the study group were significantly higher than those in the control group(P<0.05).After treatment,IL-6,TNF-αand CRP in the study group were significantly lower than those in the control group(P<0.05).No adverse reactions occurred in both groups during treatment.Conclusion:Huatan Lifei Dingchuan Decoction combined with tiotropium bromide in the treatment of elderly patients with ACOS can alleviate clinical symptoms,improve lung function,reduce inflammation,and have good safety.

关 键 词：哮喘-慢阻肺重叠综合征 噻托溴铵 化痰理肺定喘汤 肺功能 炎性因子 

分 类 号：R562.25[医药卫生—呼吸系统]