盐酸拉贝洛尔联合间苯三酚对妊娠期高血压患者血管内皮功能及氧化应激指标的影响  

Effect of labetalol hydrochloride combined with phloroglucinol on vascular endothelial function and oxidative stress indicators in patients with hypertensive disorder complicating pregnancy

作　　者：余文 王银 Yu Wen;Wang Yin(Department of Obstetrics,Pingqiao Maternal and Child Health Hospital,Xinyang,Henan 464000,China)

机构地区：[1]信阳市平桥区妇幼保健院产科,河南信阳464000

出　　处：《四川生理科学杂志》2025年第2期372-375,共4页

摘　　要：目的:探讨盐酸拉贝洛尔联合间苯三酚治疗妊娠期高血压(Hypertensive disorder complicating pregnancy,HDCP)患者的效果。方法:回顾性收集2022年1月至2024年1月期间本院收治的101例HDCP患者的临床资料,按治疗方法的不同分为对照组(静脉滴注间苯三酚40 mg,n=49)和观察组(口服盐酸拉贝洛尔100 mg+静脉滴注间苯三酚40 mg,n=52),均持续治疗至血压正常或分娩前。分析比较两组临床疗效,于治疗前后采用可见分光光度法检测过氧化氢酶(Catalase,CAT),采用气相色谱法检测丙二醛(Malondialdehyde,MDA),采用酶联免疫法检测超氧化物歧化酶(Superoxide dismutase,SOD),采用比色法检测谷胱甘肽过氧物酶(Glutathione peroxidase,GSH-Px),采用循环酶法测定同型半胱氨酸(Homocystine,Hcy),采用硝酸还原酶法检测一氧化氮(Nitric oxide,NO),采用酶联免疫法测定血管内皮生长因子(Vascular endothelial growth factor,VEGF)、内皮素-1(Endothelin-1,ET-1),并采用血压测量仪检测舒张压(Diastolic blood pressure,DBP)、收缩压(Systolic blood pressure,SBP),同时计算平均动脉压(Mean arterial pressure,MAP),观察记录两组不良妊娠结局总发生率。结果:观察组总有效率高于对照组(P<0.05)。治疗后两组SOD、GSH-Px、CAT、VEGF、NO均明显上升,高于对照组,MDA、ET-1、Hcy均明显下降,且观察组上述指标改善幅度更为显著(P<0.05)。治疗后观察组DBP、SBP、MAP低于对照组(P<0.05)。两组不良妊娠结局总发生率无明显差异(P>0.05)。结论:盐酸拉贝洛尔联合间苯三酚能提高HDCP患者治疗效果,减轻机体氧化应激,降低血压,改善血管内皮功能。Objective:To investigate the effect of labetalol hydrochloride combined with phloroglucinol on Hypertensive disorder complicating pregnancy(HDCP).Methods:The clinical data of 101 patients with HDCP admitted to our hospital from January 2022 to January 2024 were retrospectively collected.According to different treatment methods,patients were divided into a control group(intravenous infusion of phloroglucinol 40 mg,n=49)and an observation group(oral administration of labetalol hydrochloride 100 mg+intravenous infusion of phloroglucinol 40 mg,n=52).All patients were treated until their blood pressure returned to normal or before delivery.The clinical efficacy of the two groups was analyzed and compared.Catalase(CAT)was detected by visible spectrophotometry before and after treatment.Malondialdehyde(MDA)was detected by gas chromatography.Superoxide dismutase(SOD)was detected by enzyme-linked immunosorbent assay.Glutathione peroxidase(GSH-Px)was detected by colorimetry.Homocysteine(Hcy)was detected by cyclic enzyme method.Nitric oxide(NO)was detected by nitric acid reductase method.Vascular endothelial growth factor(VEGF)and endothelin-1(ET-1)were detected by enzyme-linked immunosorbent assay.The diastolic blood pressure(DBP)and systolic blood pressure(SBP)were measured using a blood pressure monitor,and the Mean arterial pressure(MAP)was calculated.The total incidence of adverse pregnancy outcomes in both groups was observed and recorded.Results:The total effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the levels of SOD,GSH-Px,CAT,VEGF,and NO in both groups increased significantly,higher than those in the control group,while the levels of MDA,ET-1,and Hcy decreased significantly,and the improvement of these indicators in the observation group was more significant(P<0.05).After treatment,the DBP,SBP,and MAP in the observation group were lower than those in the control group(P<0.05).There was no significant difference in the overall incidence of adverse pregnanc

关 键 词：盐酸拉贝洛尔 间苯三酚 妊娠期高血压 血管内皮功能 氧化应激 

分 类 号：R714.246[医药卫生—妇产科学]