81例新型布尼亚病毒感染的回顾性分析  

A retrospective study of 81 cases of novel Bunyavirus infection

作　　者：何丹丹 He Dan-dan(Department of Infection,Guangshan People's Hospital,Xinyang 465450,Henan,China)

机构地区：[1]光山县人民医院感染科,河南信阳465450

出　　处：《四川生理科学杂志》2025年第2期429-432,共4页

摘　　要：目的:分析新型布尼亚病毒感染的临床特征。方法:回顾性分析2020年3月至2022年10月期间本院收治的81例新型布尼亚病毒感染患者的临床资料。所有患者均口服利巴韦林10 mg·kg^(-1)抗病毒治疗,同时白细胞计数<4.0×10^(9)·L^(-1)者,加用粒细胞集落刺激因子;血小板计数<10×10^(9)·L^(-1)者输注血小板;血小板计数>30×10^(9)·L^(-1)者,加用丙种球蛋白,由经过培训的调查员收集新型布尼亚病毒感染的临床特征、预后情况等,并比较治疗14 d后不同预后患者实验室指标、核酸定量情况。结果:81例新型布尼亚病毒感染患者中,男性占比37.04%、女性占比62.96%,且98.77%的患者居住在丘陵或山林地区的农村地区;临床表现以发热、乏力为主,70~79岁是高发感染年龄段,夏季感染发生率最高;81例患者经治疗14 d后,有63例治愈、18例病死;病死者血小板计数、纤维蛋白原、血清钙、肾小球滤过率(Glomerular filtration rate,GFR)较治愈者低,丙氨酸氨基转移酶(Alanine aminotrarsferase,ALT)、肌钙蛋白Ⅰ(cardiac trooping I,cTnI)、肌酸激酶、肌酸激酶同工酶、凝血酶原时间(Prothrombin time,PT)、活化部分凝血活酶时间(Activated partial thromboplastin time,APTT)、钾离子、肿瘤坏死因子、D-二聚体、白介素6、白介素8、白介素10、降钙素原、γ-谷氨酰转氨酶(γ-glutamyl transpeptidase,γ-GT)、谷草转氨酶、乳酸脱氢酶、血肌酐、核酸定量较治愈者高(P<0.05)。结论:新型布尼亚病毒感染以居住在丘陵或山林地区的农村70~79岁女性为主,夏季高发,病毒载量等与患者预后有关。Objective:To analyze the clinical characteristics of the new Bunyavirus infection.Methods:Clinical data of 81 patients with new bunyavirus infection admitted to our hospital from March 2020 to October 2022 were retrospective analyzed.All patients were treated with oral ribavirin 10 mg·kg^(-1) for antiviral therapy.Those with a white blood cell count<4.0×10^(9)·L^(-1) were given granulocyte colony-stimulating factor;patients with a platelet count of<10×10^(9)·L^(-1) should receive platelet transfusions;patients with a platelet count>30×10^(9)·L^(-1) were treated with gamma globulin.The clinical characteristics and prognosis of patients with new bunyavirus infection,and compared laboratory indicators and nucleic acid quantification in patients with different prognoses after 14 days of treatment were collected.Results:Among the 81 patients infected with the new Bunyavirus,37.04%were male and 62.96%were female.98.77%of the patients lived in rural areas with hilly or mountainous terrain;The main clinical manifestations are fever and fatigue,with a high incidence of infection in the age group of 70-79 years old,and the highest incidence of infection in summer;After 14 days of treatment,63 patients were cured and 18 died;The platelet count,fibrinogen,serum calcium,and glomerular filtration rate(GFR)in patients who died were lower than those in patients who were cured.Alanine aminotransferase(ALT),cardiac troponin I(cTnI),creatine kinase,creatine kinase isoenzyme,prothrombin time(PT),activated partial thromboplastin time(APTT),potassium ion,tumor necrosis factor,D-dimer,interleukin 6,interleukin 8,interleukin 10,procalcitonin,γ-glutamyl transpeptidase(γ-GT),glutamic oxaloacetic transaminase,lactate dehydrogenase,serum creatinine,nucleic acid quantification were higher than those in patients who were cured(P<0.05).Conclusion:The new Bunyavirus infection is mainly caused by women aged 70-79 years living in rural areas with hilly or mountainous terrain,and it occurs more frequently in summer.The viral load is relat

关 键 词：新型布尼亚病毒 感染 临床特征 预后情况 

分 类 号：R512[医药卫生—内科学] R446.1[医药卫生—临床医学]