宫腔镜手术联合术后孕激素治疗对子宫内膜息肉患者雌激素、孕激素受体及复发的影响  

Effects of hysteroscopic surgery combined with postoperative progesterone on estrogen receptor,progesterone receptor,and recurrence in patients with endometrial polyps

作　　者：苏倩倩 Su Qian-qian(Department of Gynecology,Zhengzhou People's Hospital,Zhengzhou 450000,China)

机构地区：[1]郑州人民医院妇科,河南郑州450000

出　　处：《四川生理科学杂志》2025年第2期433-435,共3页

摘　　要：目的:探讨宫腔镜手术+术后孕激素治疗对子宫内膜息肉(Endometrial polyps,EP)患者雌激素受体(Estrogen Receptor,ER)、孕激素受体(Progesterone Receptor,PR)及复发的影响。方法:采用奇偶分组法将本院2022年8月至2023年10月看诊的100例EP患者分为观察组和对照组(n=50),其中对照组给予宫腔镜手术方案,观察组则在上述基础上给予术后孕激素。术后6 m对比两组治疗效果;治疗前、治疗6 m后,采用免疫组织化学染色法测定子宫内膜腺体、间质中ER、PR水平;超声测量子宫内膜厚度,通过氰化高铁血红蛋白法检测上述不同时间点血红蛋白量;统计两组治疗后的不良反应及1 y后电话随访的EP复发情况。结果:治疗6 m后,相比于对照组,观察组疗效与血红蛋白水平更高,ER、PR表达水平、子宫内膜厚度更低(P<0.05);统计两组不良反应发生情况,观察组发生率低于对照组(P<0.05);观察组复发率更低(P<0.05)。结论:EP应用宫腔镜手术+术后孕激素治疗可改善患者ER、PR水平,提升血红蛋白水平,能够降低EP复发。Objective:To explore the effects of hysteroscopic surgery+postoperative progesterone on estrogen receptor(ER),progesterone receptor(PR),and recurrence in patients with endometrial polyps(EP).Methods:According to the odd-even grouping method,100 patients with EP in the hospital were divided into a control group(n=50,hysteroscopic surgery)and an observation group(n=50,hysteroscopic surgery+postoperative progesterone)between August 2022 and October 2023.Six months after surgery,the curative effect in the two groups was compared.Before and after 6 months of treatment,levels of ER and PR in endometrial glands and mesenchyme were detected by immunohistochemical staining,endometrial thickness was measured by ultrasound and hemoglobin level was detected by cyanmethemoglobin method.The adverse reactions after treatment and EP recurrence after 1 year of telephone follow-up in the two groups were statistically analyzed.Results:Compared with the control group after 6 months of treatment,curative effect and hemoglobin were higher,while ER,PR,and endometrial thickness were lower in the observation group(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).The recurrence rate was lower in the observation group(P<0.05).Conclusion:Hysteroscopic surgery+postoperative progesterone can improve ER and PR levels,increase hemoglobin levels,and reduce disease recurrence in EP patients.

关 键 词：子宫内膜息肉 宫腔镜手术 术后孕激素 雌激素受体 孕激素受体 复发 

分 类 号：R713.4[医药卫生—妇产科学]