白蛋白/球蛋白与预后营养指数在胃癌患者中的预后意义及预测模型的建立  

Implications of albumin/globulin and prognostic nutritional index in gastric cancer patients and establishment of a predictive model

作　　者：刘茜 蒋超 冯婉婷[1] LIU Qian;JIANG Chao;FENG Wanting(Department of Oncology,Huai′an First People′s Hospital,Huai′an 223001,Jiangsu,China)

机构地区：[1]南京医科大学附属淮安第一医院肿瘤内科,江苏淮安223001

出　　处：《皖南医学院学报》2025年第1期94-98,共5页Journal of Wannan Medical College

基　　金：淮安市自然科学研究类计划项目(HAB202101)。

摘　　要：目的:探讨白蛋白/球蛋白(AGR)和预后营养指数(PNI)与胃癌患者预后的关系,并建立列线图预测模型。方法:收集2014年6月~2019年6月淮安市第一人民医院收治的286例胃癌患者的临床病理和随访资料,探讨AGR和PNI对预后的作用,并分析胃癌患者预后的影响因素,并构建预测模型。结果:AGR和PNI的最佳截断值分别为1.135、44.33。低AGR组和低PNI组的生存期(OS)和无进展生存期(PFS)均低于高值组(P<0.05)。各联合组间比较低AGR和低PNI组的OS和PFS均最短(P<0.05)。多因素COX回归分析结果显示,AGR和PNI为患者OS的影响因素(P<0.05),AGR和PNI为患者PFS的影响因素(P<0.05)。结论:高水平的AGR和PNI可以作为评估胃癌患者预后的独立保护因素。Objective:To investigate the relationship between albumin/globulin(AGR)and prognostic nutritional index(PNI)and the prognosis of patients with gastric cancer,and establish a nomogram model to predict the prognosis for this group of patients.Methods:The clinicopathological data and follow-up findings were collected from 286 gastric cancer patients treated in our hospital between June of 2014 and 2019.The role of AGR and PNI in prognosis was estimated,and the independent influencing factors for the prognosis in gastric cancer patients were analyzed.Finally,a nomogram model to predict the prognosis was established.Results:The optimal cutoff value was 1.135 and 44.33,respectively for AGR and PNI.The overall survival and progression free survival of the low AGR group and the low PNI group were lower than those of the high value group(P<0.05),and the overall survival and progression free survival were the shortest in patients in the low AGR and low PNI groups(P<0.05).The results of multivariate COX regression analysis showed that AGR and PNI were independent factors affecting the overall survival of patients(P<0.05),while AGR and PNI were independent influencing factors for progression free survival(P<0.05).Conclusion:High levels of AGR and PNI can serve as independent protective factors for evaluating the prognosis of gastric cancer patients.

关 键 词：白蛋白/球蛋白 预后营养指数 总体生存期 无进展生存期 延续护理 

分 类 号：R446.11[医药卫生—诊断学] R735.2[医药卫生—临床医学]