表面增强拉曼光谱的基底设计及其血液检测研究进展  

Substrate Design of Surface-Enhanced Raman Spectroscopy and Research Progress in the Detection of Body Fluids

作　　者：蔡云帆 许克惠 赵耀 李之婷 夏凌云[1] 王晨语 罗志晓[1] 牛丽娜 CAI Yun-Fan;XU Ke-Hui;ZHAO Yao;LI Zhi-Ting;XIA Ling-Yun;WANG Chen-Yu;LUO Zhi-Xiao;NIU Li-Na(Department of Stomatology,Taihe Hospital,Hubei University of Medicine,Shiyan 442000,China;Department of Prosthodontics,School of Stomatology,Air Force Medical University,Shaanxi Key Laboratory of Stomatology,National Clinical Research Center for Oral Diseases,State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration,Xi'an 710032,China)

机构地区：[1]湖北医药学院附属太和医院口腔医学中心,十堰442000 [2]口颌系统重建与再生全国重点实验室,国家口腔疾病临床医学研究中心,陕西省口腔医学重点实验室,空军军医大学口腔医院修复科,西安710032

出　　处：《应用化学》2025年第1期1-13,共13页Chinese Journal of Applied Chemistry

基　　金：陕西省重点科技创新团队项目(No.2020TD-033);国家口腔疾病临床医学研究中心一般基金项目(No.LCB202209)资助。

摘　　要：表面增强拉曼光谱(SERS)因其独有的快速检测、高灵敏度、低检测限和无损分析等优点,在医学检验领域有着广泛的研究。SERS增强基底的成功构建是SERS技术实现以上优点的前提。本文介绍了SERS的增强机制,在血液检测中,对其增强基底的设计进行了分类及讨论,将其分为无标签基底和有标签基底两大类,并根据材料应用的不同和基底设计的方式不同进行进一步的细分。对近年来血液检测中SERS检测应用相关文献进行了回顾,综述了在血液检验中不同类型增强基底的设计方法及应用特征。最后,对SERS增强基底在血液检验中的设计进行了总结与展望。Surface enhanced Raman spectroscopy(SERS)has been extensively studied in the field of medical testing due to its unique advantages of rapid detection,high sensitivity,low detection limits and non-destructive analysis.The successful construction of SERS substrates is essential for realizing these benefits.In this paper,the enhancement mechanism of SERS is introduced,the design of its enhanced substrate in blood detection is categorized and discussed.It is divided into two categories:label-free substrates and label substrates,and further subdivided according to different material applications and substrate design methods.A review of relevant literature on the application of SERS detection in blood testing in recent years,summarizes the design methods and application characteristics of different types of enhanced substrates in blood testing.Finally,the design of SERS-enhanced substrate in blood examination is summarized and prospected.

关 键 词：表面增强拉曼光谱 增强机制 无标签基底 有标签基底 血液检测 

分 类 号：O657.37[理学—分析化学] R446.11[理学—化学]