达格列净联合西格列汀对老年2型糖尿病患者糖脂代谢的影响  

Effect of Dapagliflozin Combined with Sitagliptin on Glycolipid Metabo⁃lism in Elderly Patients with Type 2 Diabetes Mellitus

作　　者：王小芸[1] 袁庆杰[2] 孙显臣 WANG Xiaoyun;YUAN Qingjie;SUN Xianchen(Center of Disease Control,Hanting District People's Hospital,Weifang 261100,Shandong,China;Department of Intensive Care Medicine,Hanting District People's Hospital,Weifang 261100,Shandong,China;Department 3 of Respiratory and Critical Care Medicine,Weifang Second People's Hospital,Weifang 261041,Shandong,China)

机构地区：[1]潍坊市寒亭区人民医院疾病管理中心,山东潍坊261100 [2]潍坊市寒亭区人民医院重症医学科,山东潍坊261100 [3]潍坊市第二人民医院呼吸与危重症医学科三部,山东潍坊261041

出　　处：《糖尿病新世界》2024年第21期17-20,共4页Diabetes New World

摘　　要：目的探讨达格列净联合西格列汀对老年2型糖尿病患者的干预效果及对糖脂代谢的影响。方法选择2022年5月—2024年6月潍坊市寒亭区人民医院收治的96例老年2型糖尿病患者,根据治疗方法不同分为两组。对照组(n=48)给予达格列净干预,观察组(n=48)联合西格列汀干预,比较两组糖脂代谢水平、胰岛功能指标及药物安全性。结果干预后,与对照组相比,观察组空腹血糖、餐后2 h血糖、糖化血红蛋白、总胆固醇、甘油三酯及低密度脂蛋白胆固醇水平更低,高密度脂蛋白胆固醇水平更高,差异均有统计学意义(P均<0.05)。干预后,与对照组相比,观察组空腹胰岛素、胰岛素抵抗指数更低,胰岛β细胞功能指数更高,差异均有统计学意义(P均<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论老年2型糖尿病患者在达格列净基础上加用西格列汀,可降低血糖及改善胰岛功能指标,调节机体血脂水平,药物安全性较高。Objective To investigate the intervention effect of dapagliflozin combined with sitagliptin on elderly pa-tients with type 2 diabetes mellitus and its effect on glucose and lipid metabolism.Methods From May 2022 to June 2024,96 elderly patients with type 2 diabetes mellitus admitted to Hanting District People's Hospital of Weifang were selected.According to different treatment methods,they were divided into two groups.The control group(n=48)was given dapagliflozin intervention,and the observation group(n=48)was combined with sitagliptin intervention.The lev-els of glucose and lipid metabolism,islet function indexes and drug safety were compared between the two groups.Results After intervention,compared with the control group,the levels of fasting blood glucose,2-hour postprandial blood glucose,glycated hemoglobin A1c,total cholesterol,triglyceride and low-density lipoprotein cholesterol in the observation group were lower,and the level of high-density lipoprotein cholesterol was higher,the differences were statistically significant(all P<0.05).After intervention,compared with the control group,the fasting insulin and homeo-static model assessment of insulin resistance in the observation group were lower,and the homeostatic model assess-ment ofβ-cell function was higher,the differences were statistically significant(both P<0.05).There was no signifi-cant difference in incidence of adverse reactions between the two groups(P>0.05).Conclusion The addition of sita-gliptin to dapagliflozin in elderly patients with type 2 diabetes mellitue can reduce the levels of blood glucose and im-prove islet function index,regulate the body's blood lipid levels,and have high drug safety.

关 键 词：达格列净 西格列汀 老年2型糖尿病 糖脂代谢 

分 类 号：R587.1[医药卫生—内分泌]