丹参川芎嗪注射液治疗重症急性胰腺炎的疗效  

Therapeutic Effect of Danshen Chuanxiongqin Injection(丹参川芎嗪注射液)on Severe Acute Pancreatitis

作　　者：谭小飞[1] 王佳梅[1] TAN Xiaofei;WANG Jiamei(Zigong No.1 People′s Hospital,Zigong 643000,Sichuan,China)

机构地区：[1]自贡市第一人民医院,四川自贡643000

出　　处：《辽宁中医杂志》2025年第2期57-61,共5页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的探讨重症急性胰腺炎(severe acute pancreatitis,SAP)患者采用丹参川芎嗪注射液进行治疗的疗效。方法按照随机数字表法分配原则将于89例2020年3月-2023年3月在自贡市第一人民医院重症加强护理病房(ICU)接受治疗的SAP患者分为A组(45例)和B组(44例)。A组患者采用常规治疗联合乌司他丁进行处理,在A组基础上,B组患者采用丹参川芎嗪注射液进行治疗,两组均连续治疗2周。比较两组临床指标,治疗2周后临床疗效,治疗前、治疗2周后肠道黏膜屏障功能、中医证候积分、血清淀粉酶、C反应蛋白(C-reactive protein,CRP)、脂肪酶、白细胞介素-6(interleukin-6,IL-6)水平,治疗期间并发症发生情况。结果B组治疗2周后的总有效率高于A组[93.18%(41/44)vs 75.56%(34/45),P<0.05]。与A组进行比较,B组临床症状缓解时间及平均住院时间均相对更短;治疗2周后,两组腹痛剧烈、胸闷腹胀、恶心呕吐、便溏不爽评分、血清二胺氧化酶(diamine oxidase,DAO)、D-乳酸、内毒素、淀粉酶、CRP、脂肪酶、IL-6水平与治疗前比较均降低,与A组比较,B组较低(P<0.05)。治疗期间,A组和B组并发症总发生率比较,差异无统计学意义[20.00%(9/45)VS 25.00(11/44),P>0.05]。结论丹参川芎嗪注射液治疗SAP可有效改善患者肠道黏膜屏障功能,使机体内炎症因子水平降低,并提高胰腺功能,进而可促进患者症状的改善,缩短患者恢复时间,提高疗效,且具有良好的安全性。Objective To explore the the therapeutic effect of Danshen Chuanxiongqin Injection(丹参川芎嗪注射液)on patients with severe acute pancreatitis(SAP).Methods Eighty-ninepatients with SAP who were treated in intensive care unit(ICU)of Zigong First People′s Hospital from March 2020 to March 2023 were divided into the group A(45 cases)and the group B(44 cases)according to the principle of random number table method.The patients in the group A were treated with conventional therapy combined with ulinastatin.On the basis of the group A,thosein the group B were treated with Danshen Chuanxiongqin Injection.Both groups were treated continuously for 2 weeks.The clinical indexes of the two groups were compared,including the clinical efficacy after 2 weeks of treatment,intestinal mucosal barrier function,the scoresof traditional Chinese medicine syndrome,the levels of serum amylase,C-reactive protein(CRP),lipaseand interleukin-6(IL-6)before and after treatment,and the occurrence of complications during treatment.Results The rate of total effective in the group B after 2 weeks of treatment was higher than that in the group A[93.18%(41/44)vs 75.56%(34/45),P<0.05].Compared with those in the group A,the timeof clinical symptom relief and average hospitalization in the group B was relatively shorter.After 2 weeks of treatment,the scores of severe abdominal pain,chest tightness and abdominal distension,nausea and vomitingand loose stool,the serum levels of diamine oxidase(DAO),D-lactic acid,endotoxin,amylase,CRP,lipaseand IL-6 all decreased compared with those before treatment,and compared with those of the group A,the levels and scores of the group B were lower(P<0.05).During the treatment period,there was no statistically significant difference in the total incidence of complications between the group A and the group B[20.00%(9/45)vs 25.00(11/44),P>0.05].Conclusion Danshen Chuanxiongqin Injection could effectively improve the intestinal mucosal barrier function of patients with SAP,reduce the levels of inflammatory fact

关 键 词：急性胰腺炎 重症 丹参川芎嗪注射液 炎症因子 肠道黏膜屏障功能 

分 类 号：R256.3[医药卫生—中医内科学]