桂苓温阳利水饮结合运动康复疗法治疗阳虚水泛证慢性心力衰竭效果观察  

Effect of Guiling Wenyang Lishui Decoction(桂苓温阳利水饮)Combined with Exercise Rehabilitation Therapy on Chronic Heart Failure with Edema Due to Yang Deficiency Syndrome

作　　者：吴颖 王征 陈琳 王巍 王昀 WU Ying;WANG Zheng;CHEN Lin;WANG Wei;WANG Yun(Shunyi Hospital,Beijing Hospital of Traditional Chinese Medicine,Beijing 101300,China)

机构地区：[1]北京中医医院顺义医院,北京101300

出　　处：《辽宁中医杂志》2025年第2期103-106,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：北京市自然科学基金项目(7214298)。

摘　　要：目的观察桂苓温阳利水饮结合运动康复疗法治疗阳虚水泛证慢性心力衰竭效果。方法研究总计纳入2021年8月-2023年7月该院收治阳虚水泛证慢性心力衰竭患者112例以随机数字表法分为对照组与观察组,给予对照组患者(56例)西药常规(地高辛片、沙库曲缬沙坦钠片、富马酸比索洛尔片)治疗,观察组在对照组患者治疗基础上结合桂苓温阳利水饮及运动康复疗法治疗,各组数据观察:临床疗效、治疗前后中医证候积分变化以及血清N末端前脑钠肽(N-terminal probrain natriuretic peptide,NT-proBNP)及左心室射血分数(left ventricular ejection fraction,LVEF)水平变化、白细胞介素-6(interleukin-6,IL-6)、白细胞介素-17(interleukin-17,IL-17)、超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)水平变化、6 min步行距离变化与改良明尼苏达心力衰竭生存质量量表(modified minnesota heart failure quality of life scale,C-MLHF)评分变化、不良反应。结果观察组患者治疗总有效率(94.64%,53/56)比对照组(82.14%,46/56)更高,P<0.05;各组患者治疗前中医证候积分、NT-proBNP及LVEF水平、IL-6、IL-17及hs-CRP、6 min步行距离及C-MLHF评分比较,P>0.05,治疗后各组患者中医证候积分、NT-proBNP及LVEF水平、IL-6、IL-17及hs-CRP、6 min步行距离及C-MLHF评分均改善,观察组患者治疗后中医证候积分、NT-proBNP及LVEF水平、IL-6、IL-17及hs-CRP、6 min步行距离及C-MLHF评分均优于对照组,P<0.05;各组不良反应率均较低,观察组为1.79%(1/56),对照组为3.57%(2/56),P>0.05。结论桂苓温阳利水饮结合运动康复疗法治疗阳虚水泛证慢性心力衰竭疗效良好,患者症状好转,心功能改善,运动耐力提升,生活质量改善,不良反应少。Objective To observe the effect of Guiling Wenyang Lishui Decoction(桂苓温阳利水饮)combined with exercise rehabilitation therapy on chronic heart failure with edema due to Yang deficiency syndrome.Methods A total of 112 patients with chronic heart failure with edema due to Yang deficiency syndrome admitted to the hospital from August 2021 to July 2023 were divided into control group and observation group by random number table method,and 56 patients in the control group were given conventional Western medicine treatment(digoxin tablets,sarkutrel valsartan sodium tablets,bisoprol fumarate tablets).The observation group was combined with Guiling Wenyang Lishui Decoction and exercise rehabilitation therapy on the basis of treatment of control group.Clinical efficacy,changes in TCM symptom scores before and after treatment,changes in serum levels of N-terminal probrain natriuretic peptide(NT-proBNP)and left ventricular ejection fraction(LVEF),interleukin-6(IL-6),interleukin-17(IL-17)and hypersensitive C-reactive protein(hs-CRP),and changes in 6min walking distanceand adverse reactions of the Modified Minnesota Heart Failure Quality of Life Scale(C-MLHF)of two groups were compared.Results The total effective rate of the observation group(94.64%,53/56)was higher than that of control group(82.14%,46/56)(P<0.05).TCM scores,the levels of NT-proBNP,LVEF,IL-6,IL-17 and hs-CRP,6min walking distance and C-MLHF scores were not significant in both groups before treatment(P>0.05).After treatment,TCM syndrome scores,the levels of NT-proBNP,LVEF,IL-6,IL-17 and hs-CRP,6min walking distance and C-MLHF scores were improved in both groups.And the above scores and levels in the observation group were better than those in the control group(P<0.05).The adverse reaction rate was lower in both groups)[1.79%(1/56)in observation group and 3.57%(2/56)in control group])(P>0.05).Conclusion Guiling Wenyang Lishui Decoction combined with exercise rehabilitation therapy has a good effect on the treatment of chronic heart failure with edema

关 键 词：慢性心力衰竭 阳虚水泛证 桂苓温阳利水饮 运动康复疗法 疗效 不良反应 

分 类 号：R256.22[医药卫生—中医内科学]