外泌体miRNA在女性生殖领域研究概况及中医药治疗的研究进展  

Research Overview of Exosomal miRNA in Female Reproduction and Research Progress of TCM Treatment

作　　者：李晓荣[1] 高婷 仲佳雯 秦岭 王雪怡[5] 罗玉雪 LI Xiaorong;GAO Ting;ZHONG Jiawen;QING Ling;WANG Xueyi;LUO Yuxue(General Hospital of Ningxia Medical University,Yinchuan 750000,Ningxia,China;Chengdu First People′s Hospital,Chengdu 610000,Sichuan,China;Key Laboratory of Fertility Maintenance,Ningxia Medical University,Yinchuan 750004,Ningxia,China;Key Laboratory of the Ministry of Education for the Modernization of Ethnic Minority Medicine,Ningxia Medical University,Yinchuan 750004,Ningxia,China;Yinchuan Hospital of Traditional Chinese Medicine,Yinchuan 750000,Ningxia,China)

机构地区：[1]宁夏医科大学总医院,宁夏银川750000 [2]成都市第一人民医院,四川成都610000 [3]宁夏医科大学生育力保持重点实验室,宁夏银川750004 [4]宁夏医科大学少数民族医药现代化教育部重点实验室,宁夏银川750004 [5]银川市中医医院,宁夏银川750000

出　　处：《辽宁中医杂志》2025年第2期194-199,共6页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(82260947)。

摘　　要：外泌体作为细胞间通讯的介质,近年来受到广泛的关注。尤其是外泌体携带miRNA能够调控各种疾病的发生发展,包括女性不孕性生殖疾病,有望成为多种疾病早期诊断治疗、预后的新生物标志物。此外,研究发现外泌体及其miRNA广泛参与了药物治疗过程。中医药在治疗女性多种生殖疾病中均有较好的疗效,但由于中药治疗作用多靶点、多环节、多通路的特点,直接的信号通路研究已经不能解释药物作用的具体机制,研究发现外泌体及miRNA作为间接桥梁,可能是中药作用机制研究的有效物质。因此,该文旨在通过总结外泌体miRNA对女性生殖疾病的调控作用及外泌体miRNA在中药干预作用机制中的研究,为女性生殖疾病诊疗和中医药作用机制的研究提供新的思路和文献依据。Exosomes,as mediators,have recently received much attention for intercellular communication.In particular,exosome carrying miRNA can regulate the development of various diseases,including female infertile reproductive diseases,which is expected to become a new biomarker for early diagnosis,treatment and prognosis of many diseases.Moreover,the exosomes and their miRNA were found to be widely involved in the drug treatment process.Traditional Chinese medicine has shown good therapeutic effects in treating various reproductive diseases in women.However,due to the multi-target,multi link and multi pathway characteristics of traditional Chinese medicine treatment,direct signal pathway research cannot explain the specific mechanism of drug action.Studies have found that extracellular vesicles and miRNAs,as intermediate bridges,may be effective substances for studying the mechanism of traditional Chinese medicine action.Therefore,this paper aimed to summarize the regulatory effect of exosomal miRNA on the mechanism of female reproductive diseases and the mechanism of exosomal miRNA in TCM intervention,and to provide new ideas and literature basis for the diagnosis and treatment of female reproductive diseases and the mechanism of TCM.

关 键 词：外泌体 MIRNA 生殖疾病 中药 

分 类 号：R271.1[医药卫生—中医妇科学]