升阳益胃汤加减治疗慢性萎缩性胃炎气虚湿热证的疗效观察及机理分析  

Observation on the efficacy of modified Shengyang Yiwei Decoction in treating chronic atrophic gastritis with qi-deficiency and damp-heat syndrome and analysis of its mechanism

作　　者：袁忞敏[1] 庄晓丹[2] YUAN Min-min;ZHUANG Xiao-dan(Pharmacy Department,Jiangsu University Affiliated Wujin Hospital(Xuzhou Medical University Wujin Clinical College),Changzhou 213017,China)

机构地区：[1]江苏大学附属武进医院(徐州医科大学武进临床学院)药事科,213017 [2]江苏大学附属武进医院(徐州医科大学武进临床学院)中医科,213017

出　　处：《中国现代药物应用》2025年第3期16-19,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探讨升阳益胃汤加减治疗慢性萎缩性胃炎气虚湿热证的疗效、方法和机理。方法选择60例慢性萎缩性胃炎气虚湿热证患者,14C呼气试验均为阳性,根据治疗方法不同分为对照组和试验组,每组30例。对照组接受常规西医治疗,试验组在西医治疗基础上联合升阳益胃汤加减治疗。比较两组临床疗效、不良反应发生情况及治疗前后中医证候积分、血清胃功能指标。结果试验组治疗总有效率86.67%显著高于对照组的63.33%(P<0.05)。治疗12周后,两组中医证候积分均较治疗前明显降低,且试验组治疗12周后中医证候积分(5.77±0.98)分明显低于对照组的(8.77±1.28)分(P<0.05)。治疗12周后,两组血清胃蛋白酶原Ⅰ、胃蛋白酶原Ⅰ/胃蛋白酶原Ⅱ、胃泌素-17明显高于治疗前,且试验组治疗12周后血清胃蛋白酶原Ⅰ(115.86±23.12)ng/ml、胃蛋白酶原Ⅰ/胃蛋白酶原Ⅱ(8.79±1.10)、胃泌素-17(1.06±0.28)pmol/L明显高于对照组的(81.33±19.20)ng/ml、(6.06±0.79)、(0.75±0.12)pmol/L(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论升阳益胃汤加减治疗慢性萎缩性胃炎气虚湿热证疗效显著,安全性好,值得推广利用。Objective To explore the efficacy,method and mechanism of Shengyang Yiwei Decoction in treating chronic atrophic gastritis with qi-deficiency and damp-heat syndrome.Methods A total of 60 chronic atrophic gastritis patients with qi-deficiency and damp-heat syndrome were selected,all of whom were positive in 14C breath test,and were divided into control group and experimental group according to different treatment methods,with 30 cases in each group.The control group received conventional Western medicine treatment,and the experimental group received modified Shengyang Yiwei Decoction in addition to Western medicine treatment.The clinical efficacy,adverse reactions,traditional Chinese medicine syndrome score and serological gastric function indicators before and after treatment were compared between the two groups.Results The total effective rate of the experimental group was 86.67%,which was significantly higher than 63.33% of the control group;the traditional Chinese medicine syndrome score in both groups was significantly lower than those before treatment(P<0.05).After 12 weeks of treatment,the traditional Chinese medicine syndrome score was(5.77±0.98)points in the experimental group,which was significantly lower than(8.77±1.28)points in the control group(P<0.05).After 12 weeks of treatment,the serum pepsinogen Ⅰ,pepsinogen Ⅰ/pepsinogen Ⅱ and gastrin-17 in both groups were significantly higher than those before treatment;the serum pepsinogen Ⅰ,pepsinogen Ⅰ/pepsinogen Ⅱ and gastrin-17 were(115.86±23.12)ng/ml,(8.79±1.10)and(1.06±0.28)pmol/L in the experimental group,which were significantly higher than(81.33±19.20)ng/ml,(6.06±0.79)and(0.75±0.12)pmol/L in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Shengyang Yiwei Decoction has significant efficacy and good safety in treating chronic atrophic gastritis with qi-deficiency and damp-heat syndrome,making it worthy of further promotion and utilization.

关 键 词：升阳益胃汤 慢性萎缩性胃炎 辨证论治 疗效观察 机理分析 

分 类 号：R259[医药卫生—中西医结合]