抗苗勒管激素联合性激素检测对多囊卵巢综合征的诊断价值探讨  

The value of combined detection of anti-Müllerian hormone and sex hormone in the diagnosis of polycystic ovary syndrome

作　　者：胡瑛[1] HU Ying(Department of Clinical Laboratory,The 967 Hospital of the Joint Service Support Force of the Chinese People's Liberation Army,Dalian 116000,China)

机构地区：[1]中国人民解放军联勤保障部队第九六七医院检验科,116000

出　　处：《中国现代药物应用》2025年第3期63-66,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探讨抗苗勒管激素联合性激素检测对多囊卵巢综合征(PCOS)的诊断价值。方法选取65例多囊卵巢综合征患者作为试验组,另选同期65例健康女性作为对照组。检测两组血清泌乳素(PRL)、促卵泡生成激素(FSH)、促黄体生成素(LH)、睾酮(TESTO)、雌二醇(E_(2))、孕酮(PROG)、抗苗勒管激素(AMH)。比较两组血清抗苗勒管激素与性激素指标水平;两组组内不同年龄亚组的血清抗苗勒管激素水平;抗苗勒管激素、促卵泡生成激素/促黄体生成素单一及联合检测对多囊卵巢综合征的诊断效能(敏感性、特异性)。结果试验组抗苗勒管激素(10.1±1.1)ng/ml、促黄体生成素(18.3±1.2)mIU/ml、睾酮(40.8±5.6)ng/dl明显高于对照组的(4.9±0.7)ng/ml、(8.9±0.3)mIU/ml、(24.3±2.8)ng/dl,促卵泡生成激素(4.2±0.7)mIU/ml、雌二醇(15.3±1.2)pg/ml明显低于对照组的(7.1±1.0)mIU/ml、(42.1±6.7)pg/ml(P<0.05)。试验组不同年龄亚组的血清抗苗勒管激素水平比较差异无统计学意义(P>0.05)。对照组随着年龄增加,抗苗勒管激素水平降低,对照组≤29岁组的血清抗苗勒管激素水平高于>29岁组,差异有统计学意义(P<0.05)。抗苗勒管激素联合促黄体生成素/促卵泡生成激素检测诊断多囊卵巢综合征的敏感性95.4%高于单一抗苗勒管激素检测的80.0%、单一促黄体生成素/促卵泡生成激素检测的70.8%,差异有统计学意义(P<0.05)。结论抗苗勒管激素与性激素联合诊断多囊卵巢综合征的准确性较高,对其临床诊断提供准确依据。Objective To explore the value of combined detection of anti-Müllerian hormone and sex hormone in the diagnosis of polycystic ovary syndrome(PCOS).Methods 65 patients with polycystic ovary syndrome were selected as experimental group,and another 65 healthy women during the same period were selected as the control group.The serum prolactin(PRL),follicle stimulating hormone(FSH),luteinizing hormone(LH),testosterone(TESTO),estradiol(E_(2)),progesterone(PROG),and anti-müllerian hormone(AMH)of the two groups were detected.Comparison of serum anti-Müllerian hormone and sex hormone index of the two groups,serum anti-Müllerian hormone of different age subgroups,as well as the diagnostic efficacy(sensitivity,specificity)of single and combined detection of anti-Mullerian hormone,follicle stimulating hormone/luteinizing hormone for polycystic ovary syndrome.Results In the experimental group,the anti-Müllerian hormone was(10.1±1.1)ng/ml,the luteinizing hormone was(18.3±1.2)mIU/ml,and the testosterone was(40.8±5.6)ng/dl,which were significantly higher than(4.9±0.7)ng/ml,(8.9±0.3)mIU/ml,and(24.3±2.8)ng/dl in the control group;the experimental group had follicle-stimulating hormone of(4.2±0.7)mIU/ml and estradiol of(15.3±1.2)pg/ml,which were significantly lower than(7.1±1.0)mIU/ml and(42.1±6.7)pg/ml in the control group(P<0.05).There was no significant difference in serum anti-Müllerian hormone levels among different age subgroups in the experimental group(P>0.05).In the control group,The level of anti-Müllerian hormone decreased with the increase of age,and the serum level of anti-Müllerian hormone in≤29 years old group was higher than that in>29 years old group.The difference was statistically significant(P<0.05).The sensitivity of anti-Müllerian hormone combined with luteinizing hormone/follicle-stimulating hormone in the diagnosis of polycystic ovary syndrome was 95.4%,which was higher than that of single anti-Müllerian hormone(80.0%)and single luteinizing hormone/follicle-stimulating hormone(70.8%),an

关 键 词：抗苗勒管激素 性激素 多囊卵巢综合征 诊断 

分 类 号：R711.75[医药卫生—妇产科学]