地奈德乳膏治疗寻常型斑块状银屑病的疗效探讨  

Efficacy of desonide cream in the treatment of plaque psoriasis vulgaris

作　　者：黄晓珽 HUANG Xiao-ting(Department of Dermatology,Zhao'an County Hospital,Fujian Province,Zhangzhou 363500,China)

机构地区：[1]福建省诏安县医院皮肤科,363500

出　　处：《中国现代药物应用》2025年第3期132-134,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探讨地奈德乳膏治疗寻常型斑块状银屑病的疗效。方法76例寻常型斑块状银屑病患者,随机分为对照组和研究组,每组38例。对照组选择他扎罗汀凝胶治疗,研究组选择地奈德乳膏治疗。比较两组的疗效、银屑病面积与严重性指数量表(PASI)评分、不良反应发生率和复发率。结果研究组的治疗总有效率92.1%高于对照组的65.8%(P<0.05)。研究组治疗后的PASI评分(13.2±2.3)分低于对照组的(20.5±4.7)分(P<0.05)。研究组的不良反应发生率5.3%、复发率2.6%低于对照组的21.1%、18.4%(P<0.05)。结论地奈德乳膏治疗寻常型斑块状银屑病患者能有效增强疗效,促进病情及临床症状改善,降低PASI评分,减少复发,具有较高的用药安全性。Objective To explore the efficacy of desonide cream in the treatment of plaque psoriasis vulgaris.Methods 76 patients with plaque psoriasis vulgaris were randomly divided into control group and study group,each consisting of 38 patients.The control group was treated with tazarotene gel,and the study group was treated with desonide cream.The therapeutic effect,the psoriasis area and severity index(PASI)score,the incidence of adverse reactions and the recurrence rate of the two groups were compared.Results The total effective rate of 92.1%in the study group was higher than 65.8% in the control group(P<0.05).After treatment,the PASI score of(13.2±2.3)points in the study group was lower than(20.5±4.7)points in the control group(P<0.05).The incidence of adverse reactions(5.3%)and recurrence rate(2.6%)in the study group were lower than 21.1% and 18.4% in the control group(P<0.05).Conclusion Desonide cream in the treatment of patients with plaque psoriasis vulgaris can effectively enhance the therapeutic effect,promote the improvement of patients'condition and clinical symptoms,reduce PASI score and recurrence,and have high drug safety.

关 键 词：地奈德乳膏 他扎罗汀凝胶 寻常型斑块状银屑病 疗效 安全性 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]