利多卡因联合甲泼尼龙耳后注射对突发性耳聋患者纯音测听指标的影响  

Influence of lidocaine combined with methylprednisolone postauricular injection on pure tone audiometry indicators in patients with sudden deafness

作　　者：陈荣[1] CHEN Rong(Department of Otorhinolaryngology,Funing County People's Hospital,Yancheng 224400,China)

机构地区：[1]阜宁县人民医院耳鼻咽喉科,江苏盐城224400

出　　处：《中国处方药》2025年第4期42-45,共4页Journal of China Prescription Drug

摘　　要：目的探讨突发性耳聋患者应用利多卡因联合甲泼尼龙耳后注射对纯音测听指标的影响。方法将2021年2月~2024年8月于某院就诊的64例单侧突发性耳聋患者进行随机信封编号,分为联合组与单药组,均为32例。单药组予以甲泼尼龙耳后注射,联合组在单药组基础上加用利多卡因治疗,两组疗程均为14 d。比较两组临床疗效,治疗前后两组纯音测听指标[250 Hz、500 Hz、1000 Hz频率的气导纯音听阈均值(PTA)],血浆黏度(PV)、纤维蛋白原(FIB)、红细胞聚集指数(EAI)等血液流变学指标,可溶性血管细胞黏附分子-1(sVCAM-1)、降钙素基因相关肽(CGRP)、血清活性氧簇(ROS)水平以及不良反应。结果联合组有效率高于单药组(93.75%vs.75.00%)(P<0.05);治疗2周后,两组250 Hz、500 Hz、1000 Hz下的PTA值、PV、FIB、EAI、sVCAM-1、ROS均降低(P<0.05),且联合组低于单药组(P<0.05);治疗2周后,两组CGRP均升高(P<0.05),且联合组高于单药组(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论采用利多卡因联合甲泼尼龙耳后注射治疗突发性耳聋可提高临床疗效,降低纯音听阈值,改善血液流变学及耳内微循环状态,用药安全性好。Objective To investigate the influence of lidocaine combined with methylprednisolone postauricular injection on pure tone audiometry indicators in patients with sudden deafness.Methods 64 patients with unilateral sudden deafness who were treated in the hospital from February 2021 to August 2024 were randomly envelope numbered and divided into the combined group(32 cases)and the single drug group(32 cases).The single drug group was treated with postauricular injection of methylprednisolone,while the combined group was added with lidocaine on the basis of the single drug group.Both groups were treated for 14 days.The clinical efficacy,pure tone audiometry indicators[pure-tone average(PTA)values at 250 Hz,500 Hz and 1000 Hz frequencies],hemorheological indicators[plasma viscosity(PV),fibrinogen(FIB),erythrocyte aggregation index(EAI)]and soluble vascular cell adhesion molecule-1(sVCAM-1),calcitonin gene-related peptide(CGRP),serum reactive oxygen species(ROS)before and after treatment and adverse reactions were compared between groups.Results The combined group had higher total effective rate than the single drug group(93.75%vs.75.00%)(P<0.05).After 2 weeks of treatment,the PTA values at 250 Hz,500 Hz and 1000 Hz,PV,FIB,EAI,sVCAM-1 and ROS were decreased in both groups(P<0.05),and the above indicators in combined group were lower than those in single drug group(P<0.05).CGRP was increased in the two groups after 2 weeks of treatment(P<0.05),and the CGRP in combined group was higher(P<0.05).No statistical differences were observed in the incidence rates of adverse reactions between both groups(P>0.05).Conclusion The application of lidocaine combined with methylprednisolone postauricular injection in the treatment of sudden deafness can enhance the clinical efficacy,reduce the pure tone hearing threshold,and improve the hemorheology and intraaural microcirculatory status,and it has good drug safety.

关 键 词：突发性耳聋 利多卡因 甲泼尼龙 耳后注射 纯音测听指标 

分 类 号：R764.437[医药卫生—耳鼻咽喉科]