桑通颗粒联合西药治疗重症肺炎多重耐药菌感染的疗效观察  

Therapeutic Efficacy of Sangtong Granules Combined with Western Medicine in Treating Severe Pneumonia Caused by Multidrug-resistant Bacteria

作　　者：邵玉红 吕建立 陈凡平 汪海波 赵蓉[1] Shao Yuhong;LüJianli;Chen Fanping;Wang Haibo;Zhao Rong(Shijiazhuang Hospital of Traditional Chinese Medicine,Hebei,Shijiazhuang 050051,China)

机构地区：[1]河北省石家庄市中医院,河北石家庄050051

出　　处：《中国中医急症》2025年第2期251-254,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：河北省中医药管理局2021年度中医药类科研计划课题(2021266)。

摘　　要：目的 观察桑通颗粒联合西药治疗重症肺炎多重耐药菌感染的疗效及对炎性损伤因子、转铁蛋白受体(CD71)、可溶性白细胞介素受体-2(sIL-2R)的影响。方法 采用随机数字表法将120例患者分为对照组与研究组各60例。对照组采取西医常规治疗,研究组在西医治疗基础上联合桑通颗粒治疗,两组患者最长治疗疗程均为7 d,治疗结束后观察、随访7 d。比较两组患者治疗结束后细菌清除率、痰热阻肺证中医证候积分、炎性损伤因子[C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、内皮素(ET)、一氧化氮(NO)]表达水平、CD71、s IL-2R水平和免疫水平。结果 研究组细菌清除率为95.00%,显著高于对照组的78.33%(P <0.05);治疗后两组咳嗽、发热、喘促、痰多黏稠或黄、胸闷胸痛症状积分均明显低于治疗前(P <0.05),研究组各项证候评分均明显低于对照组(P <0.05);治疗后两组血清CRP、TNF-ɑ、IL-6、ET、NO、CD71、sIL-2R含量均明显低于治疗前(P <0.05),且研究组明显低于对照组(P <0.05);治疗后两组CD8+T淋巴细胞比例明显低于治疗前(P <0.05),CD4+T淋巴细胞比例和CD4+/CD8+值明显高于治疗前(P <0.05),研究组CD8+T淋巴细胞比例明显低于对照组(P <0.05),CD4+T淋巴细胞比例和CD4+/CD8+值明显高于对照组(P <0.05)。结论 桑通颗粒联合西药治疗重症肺炎多重耐药菌感染的疗效较好,有助于清除耐药细菌,减轻机体的炎性损伤,增强机体免疫功能。Objective:To investigate the therapeutic efficacy of Sangtong Granules in combination with western medicine for treating severe pneumonia caused by multidrug-resistant bacteria,and to assess its impact on inflam⁃matory damage,serum levels of CD71,and sIL-2R.Methods:A total of 120 participants were randomly assigned to a control group and a study group,with 60 cases in each group.The control group was treated with conventional western medicine.The study group was added with Sangtong Granules on the basis of the control group.The maxi⁃mum treatment duration for both groups was 7 days,followed by a 7-day observation and follow-up period.After treatment,the bacterial clearance rate,TCM symptom scores for phlegm heat obstructing lung syndrome,and levels of inflammatory markers[C-reactive protein(CRP),tumor necrosis factor(TNF-ɑ),interleukin-6(IL-6),endothe⁃lin(ET),nitric oxide(NO)]were compared between the two groups.Additionally,levels of transferrin receptor(CD71),soluble interleukin-2 receptor(sIL-2R),and immune function were assessed.Results:The control group had a bacterial clearance rate of 78.33%,compared with 95.00%for the study group,indicating significant im⁃provement in the study group(P<0.05).After treatment,both groups showed significant reductions in symptom scores for cough,fever,wheezing,and thick,sticky,or yellow phlegm,as well as chest tightness and pain(P<0.05).Symptom scores were notably lower in the study group than in the control group(P<0.05).Additionally,lev⁃els of serum CRP,TNF-ɑ,IL-6,ET,and NO were significantly reduced in both groups after treatment(P<0.05),with even more pronounced decreases in the study group compared to the control group(P<0.05).Similarly,se⁃rum levels of CD71 and sIL-2R were significantly reduced in both groups post-treatment(P<0.05),again with more pronounced reductions in the study group than in the control group(P<0.05).Furthermore,the proportion of CD8+T lymphocytes significantly decreased in both groups post-treatment(P<0.05),whereas the proportion of

关 键 词：重症肺炎 多重耐药菌感染 桑通颗粒 炎性损伤 免疫调节 

分 类 号：R563.1[医药卫生—呼吸系统]