血府逐瘀汤联合更昔洛韦治疗带状疱疹的疗效观察  

Efficacy Observation of Xuefu Zhuyu Decoction Combined with Ganciclovir in the Treatment of Herpes Zoster

作　　者：付静[1] 兰艳 刘兴瑞 Fu Jing;Lan Yan;Liu Xingrui(Jianyang Traditional Chinese Medicine Hospital of Sichuan Province,Sichuan,Jianyang 641400,China)

机构地区：[1]四川省简阳市中医医院,四川简阳641400

出　　处：《中国中医急症》2025年第2期296-299,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：成都现代医院管理研究所2022年度科研专项课题(YJS20223010)。

摘　　要：目的 观察血府逐瘀汤联合更昔洛韦治疗带状疱疹的疗效及对体液免疫相关指标的影响。方法 患者88例随机分为观察组与对照组各44例。对照组给予更昔洛韦治疗,观察组在对照组的基础上联合血府逐瘀汤治疗。比较两组中医证候疗效、免疫球蛋白、T细胞亚群、病情严重程度以及不良反应的发生情况。结果治疗组总有效率为93.18%,高于对照组的77.27%(P <0.05);观察组总不良反应发生率为4.55%,低于对照组的18.18%(P <0.05)。治疗2周后,两组T细胞亚群(CD3+、CD4+、CD4+/CD8+)、免疫球蛋白(IgA、IgG、IgM)水平均高于治疗前,CD8+低于治疗前(P <0.05);观察组CD3+、CD4+、CD4+/CD8+和IgA、IgG、IgM水平高于对照组(P <0.01),CD8低于对照组(P <0.01)。结论 血府逐瘀汤联合更昔洛韦治疗带状疱疹可改善患者临床症状,提高患者机体免疫水平,其疗效优于单纯更昔洛韦治疗。Objective:To observe the efficacy of Xuefu Zhuyu Decoction combined with ganciclovir in the treat-ment of herpes zoster and its impact on humoral immunity-related indicators.Methods:A total of 88 patients were randomly divided into an observation group and a control group,each with 44 cases.The control group was treated with ganciclovir,while the observation group received additional treatment with Xuefu Zhuyu Decoction based on the control group's regimen.The TCM syndrome efficacy,immunoglobulin levels,T-cell subsets,severity of the condition,and incidence of adverse reactions were compared between the two groups.Results:The overall elficacy rate in the observation group was 93.18%,which was significantly higher than 77.27%in the control group(P<0.05).The total incidence of adverse reactions in the observation group was 4.55%,which was significantly lower than 18.18%in the control group(P<0.05).After two weeks of treatment,levels of T-cell subsets(CD3+,CD4+,CD4+/CD8+)and immunoglobulins(IgA,IgG,IgM)were higher than those before treatment in both groups,while CD8+was lower(P<0.05).Levels of CD3+,CD4+,CD4+/CD8+,IgA,IgG,and IgM in the observation group were higher than those in the control group(P<0.01),and CD8+was lower than that in the control group(P<0.01).Conclusion:Xuefu Zhuyu Decoction combined with ganciclovir for the treatment of herpes zoster can im-prove clinical symptoms and enhance the body's immune level,which shows better efficacy than ganciclovir alone.

关 键 词：带状疱疹 血府逐瘀汤 更昔洛韦 中医证候 体液免疫 

分 类 号：R752.12[医药卫生—皮肤病学与性病学]