祛风消痛散联合塞来昔布治疗急性痛风性关节炎的疗效观察  

Efficacy Observation of Qufeng Xiaotong Powder Combined with Celecoxib in the Treatment of Acute Gouty Arthritis

作　　者：季晓洁 胡丽芳 邹骁鸣 田晓航 李宗保 程欣 Ji Xiaojie;Hu Lifang;Zou Xiaoming;Tian Xiaohang;Li Zongbao;Cheng Xin(Wuxi Huishan Traditional Chinese Medicine Hospital,Jiangsu,Wuxi 214177,China)

机构地区：[1]江苏省无锡市惠山区中医医院,江苏无锡214177 [2]江苏省江阴市致和堂中医药研究所,江苏无锡214400

出　　处：《中国中医急症》2025年第2期310-314,共5页Journal of Emergency in Traditional Chinese Medicine

基　　金：2022年度无锡市中医药管理局中医药科技项目(ZYYB24);无锡市中医药管理局无锡市名中医工作室建设项目(锡中医[2022]9号)。

摘　　要：目的 观察祛风消痛散联合塞来昔布治疗急性痛风性关节炎(AGA)的临床疗效。方法 将80例患者随机分为对照组与试验组各40例。对照组给予塞来昔布治疗,试验组在对照组基础上加用祛风消痛散局部外敷,疗程为7 d。比较两组患者治疗前后疼痛模拟视觉量表(VAS)评分、疼痛缓解时间、C反应蛋白(CRP)、红细胞沉降率(ESR)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、前列腺素E2(PGE2)水平及总有效率、不良反应。结果 试验组疼痛缓解时间明显短于对照组(P <0.05)。试验组治疗后VAS评分及CRP、ESR、TNF-α、IL-1β、IL-6、PGE2水平均较治疗前明显降低(P <0.05),均明显低于对照组(P <0.05)。试验组总有效率为95.00%,高于对照组的80.00%(P <0.05)。两组患者治疗前后血尿酸(UA)组内及组间比较,差异无统计学意义(P> 0.05)。结论 祛风消痛散联合塞来昔布治疗AGA疗效显著,可快速缓解患者的临床症状,减轻炎症反应及抑制疼痛因子,临床疗效确切,且安全性良好。Objective:To observe the clinical efficacy of Qufeng Xiaotong Powder combined with celecoxib in treating acute gouty arthritis(AGA).Methods:80 patients were randomly divided into a control group and an ex-perimental group,each with 40 cases.The control group was treated with celecoxib,while the experimental group received additional local application of Qufeng Xiaotong Powder on top of celecoxib.The treatment course lasted for 7 days.VAS pain scores,pain relief time,C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),tu-mor necrosis factor-alpha(TNF-α),interleukin-1β(IL-1β),interleukin-6(IL-6),prostaglandin E2(PGE2)lev-els,total efficacy rates,and adverse reactions were compared between the two groups before and after treatment.Results:The pain relief time in the experimental group was significantly shorter than that in the control group(P<0.05).After treatment,the VAS scores,CRP,ESR,TNF-α,IL-1β,IL-6,and PGE2 levels in the experimental group were significantly lower than those before treatment(P<0.05)and were also significantly lower than those in the control group after treatment(P<0.05).The total efficacy rate in the experimental group was 95.00%,which was higher than 80.00%in the control group(P<0.05).There was no significant difference in serum uric acid(UA)levels within and between groups before and after treatment.Conclusion:Qufeng Xiaotong Powder com-bined with celecoxib is highly effective in treating AGA,which can provide rapid relief of clinical symptoms,re-duce inflammatory responses,and inhibit pain factors.It shows definite clinical efficacy and good safety.

关 键 词：急性痛风性关节炎 塞来昔布 祛风消痛散 中药外敷 

分 类 号：R589.7[医药卫生—内分泌]