Transition-metal-free isofunctional reaction of α,β-unsaturated ketones/nitriles  

作　　者：Runyou Ye Jialin Ming Qinyue Tao Tian-Yu Gao Jian-Heng Ye Da-Gang Yu Xiangge Zhou 

机构地区：[1]Key Laboratory of Green Chemistry&Technology of Ministry of Education,College of Chemistry,Sichuan University,Chengdu 610064,China [2]Inner Mongolia Key Laboratory of Fine Organic Synthesis,Inner Mongolia University,Hohhot 010021,China

出　　处：《Science China Chemistry》2025年第2期499-504,共6页中国科学(化学英文版)

基　　金：supported by the National Natural Science Foundation of China(22071159);Sichuan Science and Technology Program(2018JY560)。

摘　　要：Isofunctional reactions involving the cleavage of carbon-carbon double bonds(C=C)hold an important position in organic synthesis,as they allow for the restructuring of alkene carbon chains and enable the exchange of functional groups without introducing exogenous groups.Currently,these reactions are primarily divided into C=C/C=C metathesis and C=C/C=O metathesis,with most relying on the use of transition metal catalysts.We report herein a C=C/CH_(2) metathesis reaction that obviates the need for transition metals and directing groups,and is characterized by economic and straightforward operation.This reaction not only facilitates the replacement of nitriles with ketones,but also enables the replacement of ketones with nitriles,demonstrating great universality.

关 键 词：isofunctional reaction transition-metal-free C=C cleavage base-promoted Michael addition 

分 类 号：O62[理学—有机化学]