针刺对高血压靶器官保护的信号通路及调控机制研究探析  

Research Exploration on Signaling Pathways and Regulatory Mechanisms of Acupuncture in Target Organs Protection in Hypertension

作　　者：董新蕾 闫钦风 汶健 燕虹宇 陈晓琳 张丽丽[1,2,3] DONG Xinlei;YAN Qinfeng;WEN Jian;YAN Hongyu;CHEN Xiaolin;ZHANG Lili(The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China;Tianjin Key Laboratory of Acupuncture and Moxibustion Science,Tianjin 300073,China)

机构地区：[1]天津中医药大学第一附属医院,天津300193 [2]国家中医针灸临床医学研究中心,天津300381 [3]天津市针灸学重点实验室,天津300073

出　　处：《针灸临床杂志》2025年第2期1-9,共9页Journal of Clinical Acupuncture and Moxibustion

基　　金：国家自然科学基金青年项目,编号:82205257。

摘　　要：高血压是常见的心血管疾病,可导致心、脑、肾、血管及眼等多靶器官损害。针刺在降低高血压靶器官损伤、保护心、脑、肾及血管内皮方面疗效显著,主要涉及调节神经内分泌、代谢、炎症和基因表达等方面。为进一步总结目前针刺改善高血压靶器官损害的机制研究,本研究整理了知网及Pubmed数据库,从信号通路层面进行总结,以期为针刺减压、保护高血压靶器官损伤提供基因和蛋白层面的理论依据。Hypertension is a common cardiovascular disease that can cause damage to multiple target organs,including heart,brain,kidneys,blood vessels and eyes.Acupuncture has shown significant efficacy in reducing target organ damage from hypertension and in protecting heart,brain,kidneys and vascular endothelium.The underlying mechanisms primarily involve the regulation of neuroendocrine function,metabolism,inflammation,and gene expression.To further consolidate current advancements in research on how acupuncture mitigates hypertensive target organ damage,this study reviews literature from CNKI and Pubmed databases,summarizing findings from the perspective of signaling pathways.This review aims to provide theoretical support at the genetic and protein levels for the application of acupuncture in blood pressure reduction and the protection of target organs affected by hypertension.

关 键 词：高血压 针刺 靶器官 信号通路 

分 类 号：R246.1[医药卫生—针灸推拿学]