中药穴位敷贴联合互动式头针对轻度认知功能障碍患者认知功能及肠道菌群的影响  

Effects of Chinese Herbal Acupoint Application Combined with Interactive Scalp Acupuncture on Cognitive Function and Gut Microbiota in Patients with MCI

作　　者：陈强 胡益娟 CHEN Qiang;HU Yijuan(Huili People's Hospital,Huili 615100,China)

机构地区：[1]会理市人民医院,四川会理615100

出　　处：《针灸临床杂志》2025年第2期31-36,共6页Journal of Clinical Acupuncture and Moxibustion

基　　金：会理市科技计划项目,编号:2021-20。

摘　　要：目的:观察中药穴位敷贴联合互动式头针对老年轻度认知功能障碍(MCI)患者的认知功能及肠道菌群的影响。方法:选取本院确诊为MCI老年患者52例,随机分为干预组和对照组,各26例。对照组在常规认知功能训练基础上,进行互动式头针治疗;干预组在对照组基础上,加用中药穴位敷贴治疗,两组均干预8周。观察治疗前后的蒙特利尔认知评估量表(MoCA)、Fuld物体记忆评估量表(FOME)、相关肠道菌群丰度和实验室指标(GABA、SCFAs水平)并进行相关性分析。结果:在量表方面,治疗后两组MoCA、FOME均高于治疗前,差异有统计学意义(P<0.05);干预组MoCA、FOME均高于对照组,差异具有统计学意义(P<0.05)。在相关肠道菌群丰度方面,治疗后对照组各菌群丰度与治疗前差异无统计学意义(P>0.05);干预组除伯克菌目和产碱杆菌科以外,在厚壁菌门、拟杆菌门、β变形菌纲、梭菌纲、嗜血杆菌属和梭状芽孢杆菌属丰度均优于治疗前和对照组,差异具有统计学意义(P<0.05)。在实验室指标方面,治疗后对照组的SCFAs总量与治疗前,差异无统计学意义(P>0.05),而对照组的GABA以及干预组的两项指标均优于治疗前,差异有统计学意义(P<0.05);干预组在GABA、SCFAs水平均优于对照组,差异具有统计学意义(P<0.05)。相关性分析显示,FOME评分、厚壁菌门丰度、梭菌纲丰度以及GABA,均与MoCA评分呈现正相关(P<0.05)。而拟杆菌门丰度、β变形菌纲丰度、嗜血杆菌属丰度以及梭状芽孢杆菌属丰度,均与MoCA评分呈现负相关(P<0.05)。结论:在互动式头针的基础上,中药穴位敷贴特定穴位可能通过调节肠道各门、纲、目、科与属的菌群丰度,从而改善认知功能。Objective:To observe the effects of Chinese herbal acupoint application combined with interactive scalp acupuncture on cognitive function and gut microbiota in elderly patients with mild cognitive impairment(MCI).Methods:52 elderly patients diagnosed with MCI were randomly divided into the intervention group and the control group,with 26 cases in each group.Both groups were given routine cognitive function training;on which basis,the control group was also treated with interactive scalp acupuncture,and the intervention group was treated with Chinese herbal acupoint application on the treatment basis of the control group.Both groups were intervened for 8 weeks.The scores of Montreal Cognitive Assessment Scale(MoCA)and Fuld Object Memory Assessment Scale(FOME)were observed before and after the treatment in the two groups.Abundances of related gut microbiota,and the levels of GABA and MoCA were assessed before and after the treatment in the two groups.Results:The scores of MoCA and FOME were higher after the treatment than those before the treatment in both groups(P<0.05),and the scores were higher in the intervention group than those in the control group after the treatment(P<0.05).In terms of the abundances of related gut microbiota,there were no statistical differences between before and after the treatment in the control group(P>0.05);in the intervention group,except for Burkholderia and Alkaliobacteriaceae,the abundances of Firmicutes,Bacteroidetes,β-Proteobacteria,Clostridia,Haemophilus and Clostridium were higher after the treatment than those before the treatment,which were also higher than those in the control group(P<0.05).In terms of laboratory indicators,there was no statistical difference in the total amount of SCFAs between before and after the treatment in the control group(P>0.05),but the level of GABA was improved after the treatment than that before the treatment in the control group(P<0.05);the total amount of SCFAs and the level of GABA were both significantly improved after the treatment than t

关 键 词：轻度认知功能障碍 中药穴位敷贴 头针 老年 肠道菌群 

分 类 号：R246.6[医药卫生—针灸推拿学]