督脉火龙灸对慢性萎缩性胃炎脾胃虚寒证胃肠激素及氧化应激水平的影响  

Effect of Dragon Moxibustion of Du Meridian on Gastrointestinal Hormones and Oxidative Stress in Chronic Atrophic Gastritis of Deficiency-Cold of Spleen and Stomach

作　　者：胡志鹏 汪秀梅[1] HU Zhipeng;WANG Xiumei(The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,China)

机构地区：[1]新疆医科大学第一附属医院,新疆乌鲁木齐830000

出　　处：《针灸临床杂志》2025年第2期53-57,共5页Journal of Clinical Acupuncture and Moxibustion

基　　金：新疆维吾尔自治区自然科学基金,编号:2020D01C409。

摘　　要：目的:观察督脉火龙灸法对慢性萎缩性胃炎(CAG)证属脾胃虚寒者的治疗效果及对机体胃肠激素、氧化应激的调节作用。方法:选择新疆医科大学第一附属医院2021年6月-2023年6月收治的CAG患者80例,随机分为对照组与观察组,各40例。对照组给予常规西药疗法,观察组在对照组基础上给予督脉火龙灸治疗,治疗8周后比较两组临床疗效,比较两组治疗前后中医证候评分及胃黏膜评分变化,采用生命质量量表(SF-36)中生理健康(PCS)和心理健康(MCS)评分评价患者身心健康状况,ELISA测定患者血清中胃肠激素指标[胃泌素(GAS)、胃动素(MTL)和生长抑素(SS)]、氧化应激指标[超氧化物歧化酶(SOD)、丙二醛(MDA)和谷胱甘肽过氧化物酶(GSH-Px)]水平的变化。结果:治疗前,对照组、观察组患者各项指标经比较,差异无统计学意义(P>0.05);两组患者经8周治疗后,中医症候评分、胃黏膜评分较治疗前均有明显降低,PCS、MCS评分均有明显升高,差异具有统计学意义(P<0.05),同时明显降低了血清中GAS及MOD水平,提升了SS、MTL、SOD及GSH-Px水平,差异具有统计学意义(P<0.05);观察组经治疗后临床总有效率明显优于对照组,差异具有统计学意义(P<0.05),中医症候评分、胃黏膜评分及血清中GAS、MOD的水平较对照组明显降低,差异具有统计学意义(P<0.05),PCS、MCS评分及血清中SS、MTL、SOD和GSH-Px的水平较对照组明显提升,差异具有统计学意义(P<0.05)。结论:督脉火龙灸用于CAG证属脾胃虚寒者疗效良好,可有效改善患者症状和生活质量,恢复胃功能,其机制可能与调节机体胃肠激素水平及氧化应激状况相关。Objective:To observe the therapeutic effect of dragon moxibustion of Du meridian in treatment of chronic atrophic gastritis(CAG)of deficiency-cold of Spleen and Stomach and its influence to regulating gastrointestinal hormones and oxidative stress.Methods:80 CAG patients met the inclusion criteria were randomly divided into the control group and the observation group,with 40 cases in each group.The control group was treated with conventional Western medication;on which basis,the observation group was also treated with dragon moxibustion of Du meridian.After 8 weeks of treatment,the clinical effects were compared between the two groups.The scores of TCM symptoms and gastric mucosa were compared between before and after the treatment in the two groups.The scores of PCS and MCS in SF-36 were used to evaluate the physical and mental health status of the patients.The serum levels of GAS,MTL,SS,SOD,MDA and GSH-Px were measured by ELISA.Results:There were no statistical differences in the indicators between the control group and the observation group before the treatment(P>0.05).Both groups showed significant decreases in the scores of TCM symptoms and gastric mucosa after 8 weeks of treatment compared to those before the treatment(P<0.05).The scores of PCS and MCS were significantly increased(P<0.05),the serum levels of GAS and MOD were significantly decreased(P<0.05),and the serum levels of SS,MTL,SOD and GSH-Px were significantly increased after the treatment compared to those before the treatment in the two groups(P<0.05).The total clinical effective rate of the observation group was significantly higher than that of the control group(P<0.05).The scores of TCM symptoms and gastric mucosa,as well as the serum levels of GAS and MOD were significantly lower in the observation group than those in the control group(P<0.05).The scores of PCS and MCS,as well as the serum levels of SS,MTL,SOD and GSH-Px were significantly higher in the observation group than those in the control group(P<0.05).Conclusion:Dragon moxibustion o

关 键 词：慢性萎缩性胃炎 脾胃虚寒 督脉火龙灸 胃肠激素 氧化应激 

分 类 号：R246.1[医药卫生—针灸推拿学]