缺血性和出血性卒中纳米靶向给药系统研究进展  

Advances in Nano-targeted Drug Delivery Systems for Ischemic and Hemorrhagic Stroke

作　　者：汤红霞 施金伟 吴刚 TANG Hongxia;SHI Jinwei;WU Gang(Department of Pharmacy,Taizhou Hospital of Zhejiang Province,Linhai 317000,China;API Research Institute,Zhejiang Hisun Pharmaceutical Co.,Ltd.,Jiaojiang 317700,China)

机构地区：[1]浙江省台州医院药剂科,浙江临海317000 [2]浙江海正药业股份有限公司原料药研究院,浙江椒江317700

出　　处：《药学进展》2025年第1期35-43,共9页Progress in Pharmaceutical Sciences

基　　金：台州市社会发展科技计划项目(No.22ywb12)。

摘　　要：卒中是全球第二大死亡疾病以及威胁脑功能最严重的中枢神经系统疾病之一。目前针对卒中的有效治疗手段有限,同时需要克服治疗过程中会产生的缺血再灌注损伤及出血转化的风险。令人鼓舞的是,纳米技术的不断发展有望填补传统治疗策略的不足。在卒中相关病理机制的基础上,对纳米药物进入脑缺血或出血区域的主要障碍和应对策略进行系统分析。通过对缺血性和出血性卒中纳米靶向制剂的最新研究成果进行综述以及对缺血性卒中合并出血转化的纳米制剂设计提供构想,旨在为未来合理设计卒中纳米药物递送系统提供参考。Stroke is the world's second leading cause of death and one of the most serious central nervous system disorders threatening brain function.Currently,effective treatment options for stroke are limited,and the risks of ischemia-reperfusion injury and hemorrhagic conversion during treatment need to be addressed.Encouragingly,continuous development of nanotechnology has the potential to fill the gaps of conventional treatment strategies.Based on the pathological mechanisms related to stroke,the major barriers and coping strategies for nanomedicines entering ischemic or hemorrhagic region of the brain are systematically analyzed.By reviewing the latest research achievements of nano-targeted preparations for ischemic and hemorrhagic stroke,and proposing ideas for the design of nano-preparations that address ischemic stroke complicated with hemorrhagic transformation,this study aims to provide some reference for the rational design of nanomedicines delivery systems for stroke treatment in the future.

关 键 词：缺血性卒中 出血性卒中 纳米制剂 血脑屏障 

分 类 号：R94[医药卫生—药剂学]