Polyphenol-based antibacterial and antioxidative nanoparticles for improved peritonitis therapy  

作　　者：Jinhong Dong Tianyou Wang Haotian Li Jianhua Zhang Hengjie Zhang Weijie Liu Xinru You Zhipeng Gu Yiwen Li Xianchun Chen Qiang Fu 

机构地区：[1]College of Polymer Science and Engineering,State Key Laboratory of Polymer Materials Engineering,Sichuan University,Chengdu 610065,China [2]Center for Nanomedicine and Department of Anesthesiology,Brigham and Women's Hospital,Harvard Medical School,Boston,MA 02215,USA

出　　处：《Collagen and Leather》2024年第3期80-92,共13页胶原与皮革(英文)

基　　金：supported by the project of National Key R&D Program of China(2022YFB3804500)

摘　　要：The development of advanced sustainable biomedical materials with superior biosafety and bioactivity for clinical applications is highly desirable. In the present investigation, biomass-based nanoparticles(NPs) were assembled through the Mannich reaction between the plant polyphenols and the broad-spectrum antibiotic tigecycline(TG). The fabricated NPs with uniform size demonstrated excellent oxidative balance effects, pH-responsive release properties and antibacterial performances. Furthermore, the intracellular and in vivo studies confirmed that the NPs are capable of reducing oxidative damage to cells and significantly repairing tissue injury in mice with peritonitis. This work presents an effective method and idea for constructing biomass-based materials for the treatment of infection-induced diseases.

关 键 词：Biomass materials Natural polyphenols ANTIBIOTICS ANTIOXIDATIVE PERITONITIS 

分 类 号：TB3[一般工业技术—材料科学与工程]