3D打印可定制热塑性聚氨酯/聚己内酯共混物食管支架的生物力学性能  

Biomechanical properties of a customizable thermoplastic polyurethane/polycaprolactone blended esophageal stent fabricated by 3D printing

作　　者：韦归鸿 武贵林[2] 曾帅 黄圣华 张麒麟 冯军 曾博[4] 于鹏 WEI Guihong;WU Guilin;ZENG Shuai;HUANG Shenghua;ZHANG Qilin;FENG Jun;ZENG Bo;YU Peng(Scientific Research Center of Engineering Mechanics,School of Civil Engineering and Architectural,Guangxi University,Nanning 530004,China;Department of Anesthesiology,The 923th Hospital of PLA Joint Logistic Support Force,Nanning 530021,China;Guangxi Nanning Ruifeng Medical Devices Co.,Ltd.,Nanning 530000,China;Department of Thoracic Surgery,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510080,China)

机构地区：[1]广西大学土木建筑工程学院,工程力学科学研究中心,南宁530004 [2]中国人民解放军联勤保障部队第923医院麻醉科,南宁530021 [3]广西南宁锐锋医疗器械有限公司,南宁530000 [4]中山大学附属第一医院胸外科,广州510080

出　　处：《复合材料学报》2025年第1期504-513,共10页Acta Materiae Compositae Sinica

基　　金：广西南宁市技术创新引导专项项目(20204122);广西高校引进海外高层次人才“百人计划”项目。

摘　　要：食管支架在食管疾病的临床治疗中有广泛的应用。但商业食管支架尺寸固定,无法根据患者食管的几何形状进行个性化定制。通过熔融共混结合3D打印技术的方式制备了一种热塑性聚氨酯(TPU)/聚己内酯(PCL)共混物食管支架,并基于对TPU/PCL组分比例的调节,实现了对支架力学性能的调控。通过差示扫描量热、热重分析、力学试验、体外降解试验和细胞毒性检测研究了TPU/PCL共混物的理化特性及支架的各项关键指标。结果表明,TPU/PCL共混物具有良好的材料相容性和力学性能,且细胞活性为72.9%,对细胞无潜在毒性。经过为期8周的体外降解试验,支架的质量损失均小于2%,且力学性能无明显变化。3D打印TPU/PCL共混物支架优越的力学和生物学性能证明了其在食管狭窄的临床个性化治疗中具有潜在应用前景。Esophageal stents are widely used in the clinical therapy of esophageal diseases.However,commercial esophageal stents have fixed sizes and cannot be personalized according to esophageal geometry of patient.A thermoplastic polyurethane(TPU)/polycaprolactone(PCL)blend esophageal stent was prepared by melt blending combined with 3D printing technology.Based on the adjustment of TPU/PCL component ratio,the mechanical properties of the stent were regulated.The physicochemical properties of TPU/PCL blends and the key parameters of the stents were investigated by differential scanning calorimetry,thermogravimetric analysis,mechanical tests,in vitro degradation tests and cytotoxicity assays.The results show that the TPU/PCL blends exhibit favorable compatibility and mechanical properties,and the cellular activity is 72.9%with no potential toxicity to cells.The mass of the stents is less than 2%,and the mechanical properties do not change significantly after 8 weeks in vitro degradation test.The superior mechanical and biological features of 3D printed TPU/PCL blended stent demonstrate the potential application in the clinical personalized treatment of esophageal stenosis.

关 键 词：3D打印 食管支架 力学性能 TPU/PCL 生物相容性 

分 类 号：R318.01[医药卫生—生物医学工程] TB324[医药卫生—基础医学] TB332[一般工业技术—材料科学与工程]