肝移植术后急性移植物抗宿主病诊疗中国专家共识(2024版)  

Chinese expert consensus on the diagnosis and treatment of acute graft-versus-host disease after liver transplantation(2024 edition)

作　　者：中华医学会器官移植学分会 中国医师协会器官移植医师分会 吕国悦[2] 周俭[3] 徐骁 杨扬[5] 朱志军[6] 邱伟[2] 卢倩清 王婷[3] 陈康辰 申川 邓宜南 魏林[6] 陈玉国[2] 宋世飞[2] Branch of Organ Transplant of China Medical Association;Branch of Organ Transplant Physicians of Chinese Medical Doctor Association;Lyu Guoyue;Zhou Jian;Xu Xiao;Yang Yang;Zhu Zhijun(不详;First Hospital of Jilin University,Changchun 130021,China;Zhongshan Hospital,Fudan University,Shanghai 200032,China;People's Hospital of Hangzhou Medical College,Hangzhou 310014,China;The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou 510630,China;Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]不详 [2]吉林大学第一医院,长春130021 [3]上海复旦大学附属中山医院,上海200032 [4]杭州医学院附属人民医院,杭州310014 [5]中山大学附属第三医院,广州510630 [6]首都医科大学附属北京友谊医院,北京100050 [7]华大学附属北京清华长庚医院 [8]浙江大学医学院附属杭州市第一人民医院 [9]上海交通大学医学院附属仁济医院

出　　处：《中华肝脏外科手术学电子杂志》2025年第1期1-12,共12页Chinese Journal of Hepatic Surgery(Electronic Edition)

基　　金：国家自然科学基金(82241223,U20A20360)。

摘　　要：肝移植术后移植物抗宿主病(GVHD)是一种罕见但致命的并发症,发病率<1%,病死率高达85%。GVHD的发生是因供者T淋巴细胞对受者组织产生的细胞免疫反应,可累及皮肤、胃肠道和骨髓,典型临床表现包括皮疹、发热、腹泻和全血细胞减少。中华医学会器官移植学分会和中国医师协会器官移植医师分会组织行业内专家制订《肝移植术后急性移植物抗宿主病诊疗中国专家共识(2024版)》,对GVHD的发病机制、危险因素、临床表现、诊断及治疗进行详细阐述,旨在规范与优化肝移植术后GVHD的临床诊断与治疗,并提出诊断流程和治疗建议,以期改善肝移植术后GVHD受者预后。Graft-versus-host disease(GVHD)after liver transplantation is a rare but fatal complication,with the incidence rate<1%and mortality of 85%.The occurrence of GVHD is due to the cellular immune response of donor T lymphocytes to recipient tissues,which may involve the skin,gastrointestinal tract,and bone marrow.The typical clinical manifestations of GVHD include rash,fever,diarrhea,and decreased whole blood cells.The Branch of Organ Transplant of China Medical Association,combined with Branch of Organ Transplant Physicians of Chinese Medical Doctor Association organize experts to develop the Chinese Expert Consensus On The Diagnosis And Treatment Of Acute Graft-Versus-Host Disease After Liver Transplantation(2024 edition),which elaborates on the pathogenesis,risk factors,clinical manifestations,diagnosis and treatment of GVHD.The aim is to standardize and optimize the clinical diagnosis and treatment of GVHD after liver transplantation,and to propose diagnostic processes and treatment suggestions to improve the prognosis of GVHD recipients after liver transplantation.

关 键 词：肝移植 急性移植物抗宿主病 诊断 治疗 共识 

分 类 号：R657.3[医药卫生—外科学]