泪腺类器官的研究进展  

Research progress of lacrimal gland organoids

作　　者：莫亚欣 刘新宇 郭惠怡 陈鑫 陈强[1] Mo Yaxin;Liu Xinyu;Guo Huiyi;Chen Xin;Chen Qiang(Eye Hospital China Academy of Chinese Medical Sciences,Beijing 100040,China)

机构地区：[1]中国中医科学院眼科医院,中国北京市100040

出　　处：《国际眼科杂志》2025年第3期395-399,共5页International Eye Science

基　　金：国家自然科学基金资助项目(No.81503621);中国中医科学院眼科医院高水平中医医院课题(No.GSP5-32)。

摘　　要：泪腺类器官是一种新型的体外培养组织模型,与泪腺器官相似,保留了原有的泪腺组织学和分子生物学特性。该模型能够更真实地再现泪腺的生理环境、导管系统和泪膜蛋白分泌等特征。为研究泪腺的生理病理基础、建立疾病模型、开展再生医学应用和药物筛选提供了新的平台。目前,类器官技术不断发展,体外培养泪腺的方法不断更新,逐渐克服了培养难度、成本以及培养时间等方面的问题,具有广泛的应用前景。文章总结了国内外泪腺类器官研究的最新进展,探讨了泪腺类器官的发展、3D构建技术以及在临床应用方面的潜力。以期为泪腺损伤性疾病的临床研究提供新的思路,促进泪腺类器官在药物研发、个性化诊疗等领域的更广泛应用。The lacrimal gland organoids are innovative in vitro cultured tissue model that mimics the lacrimal gland,retaining its original histological and molecular biological properties.This model can more accurately reproduce the physiological environment of the lacrimal gland,including its ductal system and tear film protein secretion.It offers a new platform for studying the physiopathological basis of the lacrimal gland,establishing disease models,conducting regenerative medicine applications,and performing drug screening.Currently,organoids technology is continuously evolving,with ongoing updates to the methods for in vitro culturing of the lacrimal gland.These advancements gradually address challenges related to cultivation complexity,cost,and time,demonstrating a wide range of application potential.In this paper,we summarize the latest progress in lacrimal gland organoids research both domestically and internationally,exploring the development of lacrimal gland organoids,3D construction technologies,and their potential for clinical applications,in order to provide new insights for clinical research on lacrimal gland-related diseases and to promote broader application of lacrimal gland organoids in drug development and personalized diagnosis and treatment.

关 键 词：类器官 泪腺 3D构建技术 临床应用 药物研发 

分 类 号：R73[医药卫生—肿瘤]