性激素与催乳素诱导蛋白在圆锥角膜中的作用研究  

Study on the role of sex hormones and prolactin induced proteins in keratoconus

作　　者：陈兆乾 张文芳[1] 高璐 张妮娜 李纪新 Chen Zhaoqian;Zhang Wenfang;Gao Lu;Zhang Nina;Li Jixin(Department of Ophthalmology,the Second Hospital&Clinical Medical School,Lanzhou University,Lanzhou 730000,Gansu Province,China)

机构地区：[1]兰州大学第二医院(第二临床医学院)眼科,中国甘肃省兰州市730000

出　　处：《国际眼科杂志》2025年第3期410-415,共6页International Eye Science

摘　　要：圆锥角膜(KC)是一种由多种因素引起的眼科疾病,发病机制尚不明确。性激素受体在角膜上皮层、基质层和内皮细胞层中均有分布,近年来发现性激素及催乳素诱导蛋白(PIP)可对角膜产生影响,水平波动时对角膜的影响更加剧烈。文章综述了大量性激素及PIP如何影响角膜的研究和相关临床研究后,发现性激素和PIP在KC患者中也发挥作用,且对KC的发生发展产生影响,同时也发现妊娠哺乳女性也可能易发KC。而性激素和PIP也有潜力成为新的诊断和治疗靶点,文章在提供了新观点的同时也为临床实践提供重要参考。Keratoconus(KC)is a blinding eye disease caused by a variety of factors,with its pathogenesis still not well understood.In recent years,it has been discovered that sex hormones and prolactin-induced protein(PIP)have a profound impact on the cornea,with more noticeable changes when there are abnormalities in their body content.It has been found that various sex hormone receptors are distributed in the cornea.Based on this,this article reviews a multitude of studies on how sex hormones and PIP affect the cornea,along with relevant clinical research.It has been observed that sex hormones and PIP also play a role in KC patients and influence the occurrence and progression of KC.Additionally,it has been noted that pregnant and lactating women may be more susceptible to KC.Sex hormones and PIP have the potential to become new diagnostic and therapeutic targets.This article not only provides new insights but also offers important references for clinical practice.

关 键 词：圆锥角膜 性激素受体 雌激素 雄激素 催乳素诱导蛋白 临床研究 

分 类 号：R71[医药卫生—妇产科学]