益精活血方联合维生素E治疗肾虚血瘀型精子DNA碎片指数异常的临床观察  

The clinical Observation of Yijinghuoxue Fang with Vitamin E on Abnormal Sperm DNA Fragmentation Index with Kidney Deficiency and Blood Stasis

作　　者：李堂林[1] 翁治委[2] 周少虎[2] LI Tanglin;WENG Zhiwei;ZHOU Shaohu(Department of Reproductive Health,Zhanjiang maternity and child care center,Zhanjiang 524038,China;Department of Reproductive Medicine,The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,China)

机构地区：[1]湛江市妇幼保健院生殖健康科,广东湛江524038 [2]广州中医药大学第一附属医院生殖医学科,广东广州510405

出　　处：《云南中医药大学学报》2025年第1期48-52,共5页Journal of Yunnan University of Chinese Medicine

摘　　要：目的探讨益精活血方联合维生素E治疗精子DNA碎片指数异常的临床疗效。方法符合纳入标准的精子DNA碎片指数异常、中医辨证属于肾虚血瘀型患者60例,分为治疗组和对照组,根据患者治疗需求2组分别纳入30例。治疗组给予益精活血方和维生素E联合治疗,同时采取生活习惯方式干预,对照组采用生活习惯方式干预,疗程为3个月,观察治疗前后患者精子DNA碎片指数及精子浓度、前项运动率、精子总活力、精子正常形态率等指标变化情况,评估临床疗效。结果治疗前后精子DFI值采用t检验对比,治疗后2组精子DFI均较治疗前明显降低,具有统计学差异(P<0.05),治疗后治疗组较对照组低,存在明显统计学差异(P<0.05)。在精液常规相关参数方面,对照组精子浓度、精子总数、前项运动率、精子总活力和正常形态治疗后与治疗前比较,均无统计学差异(P>0.05);治疗组精子总数治疗后较治疗前升高,但无统计学差异(P>0.05),精子浓度、前项运动率、精子总活力、正常形态治疗后均较治疗前升高,具有统计学差异(P<0.05);治疗后治疗组前项运动率、精子总活力、正常形态均较对照组高,且具有统计学差异(P<0.05)。结论生活习惯方式干预和益精活血方联合维生素E均可以降低精子DNA碎片指数,益精活血方联合维生素E能够更有效的降低精子DNA碎片指数,且在提高精子前向运动率、精子活力和改善精子形态上疗效显著。Objective To explore the effect of Yijing Huoxue Fang with Vitamin E on abnormal sperm DNA fragmentation index with kidney deficiency and blood stasis men.Methods Follow the inclusion criteria investigation has made,60 patients diagnosed as abnormal sperm DNA fragmentation index with kidney deficiency and blood stasis in Chinese medicine syndrome differentiation,divided into treatment group and control group according to the treatment needs of the patients,30 cases were included in the two groups respectively.Treatment group prescription to Yijing Huoxue Fang and Vitamin E,combine with lifestyle intervention therapy;control group adopt lifestyle intervention treatment,lasting for 3 months.Observe sperm DNA fragmentation index、sperm concentration、sperm motility(PR,PR+NP)、normal sperm morphology rate before and after treatment,and the clinical efficacy Evaluated.Results Use t-test compare sperm DNA fragmentation index before and after treatment,there was significant decreased after treatment in both treatment group and control group(P<0.05);and the treatment group was lower than the control group after treatment,there was significant statistical difference(P<0.05).in parameters of semen,no significant difference were observed by sperm concentration、total sperm count、progressive motility,total motility and normal sperm morphology rate in control group between before and after treatment(P>0.05);in treatment group,total sperm count after treatment was increased than before,but no significant difference(P>0.05),in sperm concentration,progressive motility,total motility and normal sperm morphology rate,they were significant improvement(P<0.05);after treatment,the progressive motility、total motility and normal morphology of the treatment group were higher than those of the control group,and the difference were statistically significant(P<0.05).Conclusion Lifestyle interventions and the combination of Yijinghuoxue Fang and vitamin E can both reduce the sperm DNA fragmentation index,and Yijinghuoxue fang with V

关 键 词：精子DNA碎片指数 益精活血方 维生素E 生活习惯方式干预 

分 类 号：R277.5[医药卫生—中医学]