A型肉毒毒素对鼻尖美容作用的临床研究  

Clinical study on cosmetic effect of botulinum toxin A on nasal tip

作　　者：邵德亮 石杰[1] 高婧囡 韩明倩 古东江 刘晓光 袁继龙[1] SHAO Deliang;SHI Jie;GAO Jingnan;HAN Mingqian;GU Dongjiang;LIU Xiaoguang;YUAN Jilong(Department of Plastic Surgery,The People's Hospital of Liaoning Province,Shenyang 110016,China)

机构地区：[1]辽宁省人民医院整形美容外科,辽宁沈阳110016 [2]深圳名丽医疗美容门诊部微整形科,广东深圳518000 [3]沈阳北方整形外科医院整形外科,辽宁沈阳110000

出　　处：《中国美容整形外科杂志》2025年第1期35-37,I0010,共4页Chinese Journal of Aesthetic and Plastic Surgery

摘　　要：目的观察鼻尖区域单次、多点注射A型肉毒毒素的美容作用和不良反应。方法自2022年6月至2023年4月,深圳名丽医疗美容门诊部对47例求美者进行了鼻尖区域单次、多点、小剂量注射A型肉毒毒素。在注射前、注射后4周、注射后12周收集鼻尖部相关统计数据,并进行满意度评价。采用重复测量方差分析和非参数检验进行数据分析,IPA法进行满意度分析。结果所有求美者均未出现不良反应及并发症。注射前、注射后4周、注射后12周,鼻尖突度呈增加改变,差异具有统计学意义(P<0.001);鼻尖宽度缩小,差异具有统计学意义(P<0.001);鼻尖毛孔评级提升,差异具有统计学意义(P<0.001);鼻尖油脂分泌减少,差异具有统计学意义(P<0.05)。满意度IPA分析结果显示,求美者对鼻尖突度、鼻尖宽度改善预期和满意度均低于平均值,对鼻尖毛孔大小、鼻尖油脂分泌改善预期和满意度均高于平均值。结论A型肉毒毒素注射鼻尖安全性较高,极少有不良反应和并发症。其在缩小毛孔、减少油脂分泌等改善皮肤质量方面效果显著,满意度较高;在增加鼻尖突度、缩小鼻尖宽度等方面虽有统计学意义但满意度较低。Objective To observe the cosmetic effects and adverse reactions of single and multi-point botulinum toxin A injection in the nasal tip region.Methods From June 2022 to April 2023,47 subjects were injected with botulinum toxin A.The experimental data were collected before injection,4 weeks after injection,and 12 weeks after injection.Repeated measures analysis of variance and non-parametric test were used for data analysis,and IPA method was used for satisfaction analysis.Results All subjects experienced no adverse reactions or complications.The nasal tip protrusion increased after injection,with a statistically significant change(P<0.001);the nasal tip width decreased,with a statistically significant change(P<0.001);the rating of pores on the nasal tip improved,with a statistically significant change(P<0.001);the amount of sebum secretion on the nasal tip decreased,with a statistically significant change(P<0.05).The IPA satisfaction analysis results showed that the subjects'expectations and satisfaction with improvements in nasal tip protrusion,and width were lower than average,while their expectations and satisfaction with improvements in pores and sebum secretion were higher than average.Conclusion Botulinum toxin A injection into the nasal tip is safe with a low incidence of adverse reactions and complications.Its effect on improving skin conditions such as reducing pores and sebum secretion is significant,with high satisfaction;its effect on increasing nasal tip protrusion and reducing nasal tip width,although statistically significant,has lower satisfaction.

关 键 词：A型肉毒毒素 鼻尖美容 临床研究 

分 类 号：R765.9[医药卫生—耳鼻咽喉科]