白发形成机制及研究前景  

The mechanism and research prospects of white hair formation

作　　者：刘宇航 肖志波[1] LIU Yuhang;XIAO Zhibo(Department of Plastic Surgery,The Second Afiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第二医院整形外科,黑龙江哈尔滨150001

出　　处：《中国美容整形外科杂志》2025年第1期64-64,I0005-I0008,共5页Chinese Journal of Aesthetic and Plastic Surgery

摘　　要：白发是人体衰老最直观的表现之一。虽然目前尚不明确遗传因素在白发中的具体作用,但研究发现,氧化应激、情绪压力、神经内分泌调节、疾病与体内所含营养、微量元素等都可能与白发的生成相关。毛囊中黑色素的生成与毛发生长周期的新生阶段严格耦合,在色素合成过程中各种激素与生物因子调控下,黑色素干细胞自我缺陷,以及黑色素细胞合成障碍可能是白发生成的关键。现就白发形成的机制以及对白发逆转的研究与展望作一综述。Hair graying is one of the most intuitive phenotypes of human aging.Although the specific role of genetic factors in gray hair is still uncertain,studies have found that oxidative stress,emotional stress,neuroendocrine regulation,diseases,and trace elements contained in the body may all be related to the generation of white hair.Melanin production in hair follicles is strictly coupled to the nascent stage of the hair growth cycle.Melanin stem cell self-maintenance defects and melanocyte synthesis disorders under the regulation of various hormones and biological factors in the process of pigment synthesis may be the key to the generation of white hair.This article reviews the recent research on the mechanism of white hair formation and the future prospects for the prevention and treatment of white hair from different aspects.

关 键 词：白发 毛囊 黑色素细胞 黑色素干细胞 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]