血必净注射液联合维生素C、氢化可的松治疗脓毒性休克患者的临床效果及对预后的影响  

Clinical Effect of Xuebijing Injection Combined with Vitamin C and Hydrocortisone in the Treatment of Patients with Septic Shock and Its Influence on Prognosis

作　　者：祝志刚 郑燕 吴超骏 ZHU Zhigang;ZHENG Yan;WU Chaojun(Intensive Care Department of Shangrao Municipal Hospital,Shangrao 334000,China)

机构地区：[1]上饶市立医院重症医学科,江西上饶334000

出　　处：《中国医学创新》2025年第4期5-9,共5页Medical Innovation of China

基　　金：上饶市指导性科技计划项目(2023CZDX143)。

摘　　要：目的:观察血必净注射液联合维生素C、氢化可的松治疗脓毒性休克患者的临床效果及对预后的影响。方法:选取2023年1月—2024年3月上饶市立医院80例脓毒性休克患者,以随机数字表法分为两组,各40例,对照组给予维生素C和氢化可的松注射治疗,观察组在此基础联合血必净注射液治疗,比较两组序贯器官衰竭评估(SOFA)评分、心肌损伤指标与凝血指标、预后情况及不良反应。结果:治疗后,两组SOFA评分,肌酸激酶同工酶(CK-MB)、B型脑钠肽(BNP)、乳酸脱氢酶(LDH)、肌钙蛋白I(cTnI)水平均降低,观察组上述指标均低于对照组(P<0.05);治疗后,两组各凝血指标均较治疗前改善,观察组凝血酶时间、活化部分凝血活酶时间、凝血酶原时间均长于对照组,纤维蛋白原水平低于对照组(P<0.05);观察组ICU停留时间短于对照组,住院死亡率低于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:血必净注射液联合维生素C、氢化可的松可缓解脓毒性休克患者病情,改善患者心肌功能与凝血功能,促进预后转归,安全可靠。Objective:To observe the clinical effect of Xuebijing Injection combined with Vitamin C and Hydrocortisone in the treatment of septic shock patients and its influence on prognosis.Method:A total of 80 patients with septic shock from Shangrao Municipal Hospital from January 2023 to March 2024 were selected and divided into two groups by random number table method,with 40 cases in each group.The control group was given Vitamin C and Hydrocortisone Injection treatment,and the observation group was given combined treatment with Xuebijing Injection on this basis.The sequential organ failure assessment(SOFA)score,myocardial injury index and coagulation index,prognosis and adverse reactions were compared between the two groups.Result:After treatment,SOFA score,creatine kinase isoenzyme(CK-MB),B-type brain natriuretic peptide(BNP),lactate dehydrogenase(LDH),and cardiac troponin I(cTnI)levels in both groups were decreased,and the above indexes in observation group were lower than those in control group(P<0.05).After treatment,thrombin time,activated partial thrombin time and prothrombin time in observation group were longer than those in control group,and fibrinogen level was lower than that in control group(P<0.05).The ICU stay time of observation group was shorter than that of control group,and the in-hospital mortality was lower than that of control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combined treatment with Xuebijing Injection,Vitamin C and Hydrocortisone can alleviate the condition of patients with septic shock,and improve their myocardial function and coagulation function,and promote the prognosis of regression,which is safe and reliable.

关 键 词：血必净注射液 维生素C 氢化可的松 脓毒性休克 

分 类 号：R459.7[医药卫生—急诊医学]