甲巯咪唑联合振源胶囊对甲亢患者血清FT3、FT4、TSH水平的影响  

Effects of Thiamazole Combined with Zhenyuan Capsules on Serum FT3,FT4 and TSH Levels in Hyperthyroidism Patients

作　　者：邹俊文 胡媛 陈远鹏 ZOU Junwen;HU Yuan;CHEN Yuanpeng(Department of Endocrine,Ruijin People's Hospital,Ruijin 342500,China)

机构地区：[1]瑞金市人民医院内分泌科,江西瑞金342500 [2]瑞金市人民医院神经内科,江西瑞金342500

出　　处：《中国医学创新》2025年第4期36-40,共5页Medical Innovation of China

摘　　要：目的:探讨甲巯咪唑联合振源胶囊对甲亢患者血清游离三碘甲状腺原氨酸(free triiodothyronine,FT3)、游离甲状腺素(free tetraiodothyronine,FT4)、促甲状腺激素(thyroid stimulating hormone,TSH)水平的影响。方法:回顾性选择2021年4月—2024年1月瑞金市人民医院收治的甲亢患者102例,根据治疗方法不同分为对照组49例和观察组53例。对照组患者采用甲巯咪唑治疗,观察组患者在对照组基础上联合振源胶囊进行治疗,均连续治疗3个月。对比两组患者的临床疗效、甲状腺功能、炎症因子、不良反应情况。结果:观察组患者总有效率(98.11%)高于对照组(83.67%),差异有统计学意义(P<0.05);治疗后,与对照组患者相比,观察组患者FT3、FT4、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、超敏C反应蛋白(hypersensitive C reactive protein,hs-CRP)和白细胞介素-6(interleukin-6,IL-6)水平均低,TSH水平高(P<0.05);观察组患者总不良反应发生率(5.66%)低于对照组(18.37%),差异有统计学意义(P<0.05)。结论:甲巯咪唑联合振源胶囊治疗甲亢可有效减轻患者的炎症反应,改善甲状腺功能,增强效果,安全性高。Objective:To explore the effect of Thiamazole combined with Zhenyuan Capsules on serum free triiodothyronine(FT3),free tetraiodothyronine(FT4)and thyroid stimulating hormone(TSH)levels in patients with hyperthyroidism.Method:A total of 102 patients with hyperthyroidism admitted to Ruijin People's Hospital from April 2021 to January 2024 were retrospectively selected and divided into the control group(n=49)and the observation group(n=53)according to different treatment methods.The control group was treated with Thiamazole treatment,observation group was treated with Zhenyuan Capsules on the basis of the control group.All patients were treated for 3 months.The clinical efficacy,thyroid function,inflammatory factors and adverse reactions of the two groups were compared.Result:The total effective rate of the observation group(98.11%)was higher than that of the control group(83.67%),the difference was statistically significant(P<0.05).After treatment,compared with the control group,FT3,FT4,tumor necrosis factor-α(TNF-α)and hypersensitive C reactive protein(hsCRP)and interleukin-6(IL-6)levels in the observation group were lower,and TSH level was higher(P<0.05).The total adverse reaction rate of the observation group(5.66%)was lower than that of the control group(18.37%),the difference was statistically significant(P<0.05).Conclusion:Thiamazole combined with Zhenyuan Capsules can effectively relieve the inflammatory response of patients with hyperthyroidism,improve thyroid function,enhance efficacy and have high safety.

关 键 词：甲巯咪唑 振源胶囊 甲亢 甲状腺功能 

分 类 号：R581.1[医药卫生—内分泌]